Serum Uric Acid Levels and Uric Acid/Creatinine Ratios in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients: Are These Parameters Efficient Predictors of Patients at Risk for Exacerbation and/or Severity of Disease?

被引：32

作者：

Kocak, Nagihan Durmus ^{[1
]}

Sasak, Gulsah ^{[2
]}

Akturk, Ulku Aka ^{[1
]}

Akgun, Metin ^{[3
]}

Boga, Sibel ^{[1
]}

Sengul, Aysun ^{[4
]}

Gungor, Sinem ^{[1
]}

Arinc, Sibel ^{[1
]}

机构：

[1] Sureyyapasa Chest Dis & Thorac Surg Educ & Res Ho, Dept Pulm Dis, Istanbul, Turkey

[2] Medeniyet Univ, Goztepe Educ & Res Hosp, Dept Nephrol, Istanbul, Turkey

[3] Ataturk Univ, Sch Med, Dept Pulm Dis, Erzurum, Turkey

[4] Kocaeli Derince Educ & Res Hosp, Dept Pulm Dis, Kocaeli, Turkey

来源：

MEDICAL SCIENCE MONITOR | 2016年 / 22卷

关键词：

Creatinine; Disease Progression; Oxidative Stress; Pulmonary Disease; Chronic Obstructive; Spirometry; Uric Acid; QUALITY-OF-LIFE; CREATININE RATIO; PRESSURE; TRIAL; LUNG;

D O I：

10.12659/MSM.897759

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Serum uric acid (sUA) levels were previously found to be correlated with hypoxic states. We aimed to determine the levels of sUA and sUA/creatinine ratios in stable COPD patients and to evaluate whether sUA level and sUA/creatinine ratio can be used as predictors of exacerbation risk and disease severity. Material/Methods: This cross-sectional study included stable COPD patients and healthy controls. The sUA levels and sUA/creatinine ratios in each group were evaluated and their correlations with the study parameters were investigated. ROC analyses for exacerbation risk and disease severity were reported. Results: The study included 110 stable COPD patients and 52 healthy controls. The mean sUA levels and sUA/creatinine ratios were significantly higher in patients with COPD compared to healthy controls. The most common comorbidities in COPD patients were hypertension, diabetes, and coronary artery disease. While sUA levels were significantly higher in patients with hypertension (p=0.002) and malignancy (p=0.033), sUA/creatinine ratios was higher in patients with malignancy (p=0.004). The ROC analyses indicated that sUA/creatinine ratios can be more useful than sUA levels in predicting exacerbation risk (AUC, 0.586 vs. 0.426) and disease severity (AUC, 0.560 vs. 0.475) especially at higher cut-off values, but with low specificity. Conclusions: Our study suggested that sUA levels and sUA/creatinine ratios increased in patients with stable COPD, especially among patients with certain comorbidities compared to healthy controls. At higher cut-off values, sUA levels and especially sUA/creatinine ratios, might be useful in predicting COPD exacerbation risk and disease severity. Also, their association with comorbidities, especially with malignancy and hypertension, may benefit from further investigation.

引用

页码：4169 / 4176

页数：8

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