Review of conditioning regimens for haplo-identical donor transplants using post-transplant cyclophosphamide in recipients of G-CSF mobilised peripheral stem cell

被引:3
作者
Patil, Sushrut [1 ,2 ]
Potter, Victoria [3 ]
Mohty, Mohamad [4 ]
机构
[1] Alfred Hosp, Melbourne, Vic, Australia
[2] Monash Univ, Melbourne, Vic, Australia
[3] Kings Coll Hosp London, London, England
[4] Sorbonne Univ, Serv Hematol Clin & Therapie Cellulaire, Hop St Antoine, INSERM,UMRs 938, Paris, France
关键词
Haplo-identical transplantation; Peripheral stem cells; Post-transplant cyclophosphamide; BONE-MARROW-TRANSPLANTATION; HEMATOLOGIC MALIGNANCIES; BLOOD; SIROLIMUS;
D O I
10.1016/j.ctrv.2020.102071
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Haplo-identical transplant is being increasingly used in patients who do not have a readily available matched related or unrelated donor. Post-transplant cyclophosphamide's use due to its simplicity and documented efficacy has made this approach readily employable across diverse transplant centres across the globe. The outcomes of regimens used for conditioning in recipients of bone marrow are at times in variance to that from more commonly employed G-CSF mobilised peripheral stem cell (PBSC). This review highlights various conditioning regimens used in PBSC recipients, with emphasis on toxicities, practicalities and transplant related outcomes of relapse, non-relapse mortality and graft versus host disease.
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页数:5
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