Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220

被引：91

作者：

Du, Feng-Yu ^{[1
,2
]}

Li, Xiao-Ming ^{[1
]}

Li, Chun-Shun ^{[1
]}

Shang, Zhuo ^{[1
]}

Wang, Bin-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 14期

关键词：

Marine endophyte; Eurotium cristatum; Indole alkaloid; Antimicrobial activity; Brine shrimp inhibition; METABOLITES; DERIVATIVES; ISOLATE;

D O I：

10.1016/j.bmcl.2012.05.088

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new indole alkaloids, namely, cristatumins A-D (1-4), along with six known congeners (5-10) were identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus isolated from the marine alga Sargassum thunbergii. The structures of these compounds were established on the basis of extensive spectroscopic analysis. Each of these compounds was evaluated for antimicrobial and insecticidal activity. Compounds 1 and 9 showed antibacterial activity against Escherichia coli and Staphyloccocus aureus, respectively, while compounds 2, 6, and 7 exhibited moderate lethal activity against brine shrimp. Preliminary structure-activity relationships were also discussed. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4650 / 4653

页数：4

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