Zinc(II) complexes of tripodal peptides mimicking the zinc(II)-coordination structure of carbonic anhydrase

被引：29
|
作者：
Herr, U
Spahl, W
Trojandt, G
Steglich, W
Thaler, F
van Eldik, R
机构：
[1] Univ Munich, Inst Organ Chem, D-80333 Munich, Germany
[2] Univ Erlangen Nurnberg, Inst Anorgan Chem, D-91058 Erlangen, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 05期
关键词：
peptides; mimetics; histidine ligand; carbonic anhydrase; metal complex;
D O I：
10.1016/S0968-0896(98)00180-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new tripodal peptide ligands with histidine side chains have been synthesized and were shown to form stable zinc(II) complexes. Their NMR and mass spectra indicate a structure that is analogous to the active center of carbonic anhydrase. Both the ligands and the zinc complexes were titrated potentiometrically in order to obtain the pK(a) values for the coordinated water of the zinc complexes; due to the low solubility of the complexes only estimates could be obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：699 / 707
页数：9
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