Biomimetic NAD+ models for tandem cofactor regeneration, horse liver alcohol dehydrogenase recognition of 1,4-NADH derivatives, and chiral synthesis

被引：1

作者：

Lo, HC ^{[1
]}

Fish, RH ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 03期

关键词：

asymmetric synthesis; biomimetic synthesis; cofactors; enzyme catalysis; redox chemistry;

D O I：

10.1002/1521-3773(20020201)41:3<478::AID-ANIE478>3.0.CO;2-K

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two tandem catalysis approaches: first, a cofactor regeneration procedure with an NAD+ model and [Cp*Rh(bpy)H]+, which was formed in situ, provided the 1,4-NADH analogue 1. Cofactor 1 was then used with horse liver alcohol dehydrogenase (HLADH) for the conversion of prochiral ketones into chiral alcohol (e.g. 2 → 3).

引用

页码：478 / 481

页数：4

共 36 条

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