Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid

被引：29

作者：

Ramachandran, Lakshmy ^{[1
]}

Nair, Cherupally Krishnan Krishnan ^{[2
]}

机构：

[1] Amala Canc Res Ctr, Trichur, India

[2] Pushpagiri Inst Med Sci & Res Ctr, Tiruvalla, India

来源：

NANOMATERIALS AND NANOTECHNOLOGY | 2011年 / 1卷 / 02期

关键词：

silver nanoparticle; lipoic acid; anti-inflammatory; anti tumor; radiotherapy; NANOCRYSTALLINE SILVER; OXIDE NANOPARTICLES; CONTACT-DERMATITIS; DIHYDROLIPOIC ACID; OXIDATIVE STRESS; IN-VITRO; RADIATION; ANTIOXIDANT; PROTECTION; INFLAMMATION;

D O I：

10.5772/50956

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Silver (SN) nanoparticles were re-dispersed in aqueous solution of Pluronic F127 and complexed with the antioxidant, alpha-Lipoic acid (LA). The nanoparticle - LA complex (SN-LA) was characterized using SEM. SN-LA exhibited DPPH radical scavenging activity in vitro and anti-inflammatory activity against acute and chronic paw models of edema in mice. SN-LA protected mice from whole body gamma radiation induced body weight losses and mortality revealing its radioprotecting capacity. Meanwhile, SN-LA administration to tumour-bearing mice prior to whole body gamma radiation exposure, aided in better tumour growth delay. The results suggest the feasibility in using SN-LA as a therapeutic adjuvant during cancer radiotherapy.

引用

页码：17 / 24

页数：8

共 54 条

[1] The Effect of Lipoic Acid on Antioxidant Status and Lipid Peroxidation in Rats Exposed to Chronic Restraint Stress [J].