Omic techniques in systems biology approaches to traditional Chinese medicine research: Present and future

被引：131

作者：

Buriani, Alessandro ^{[1
,2
,3
]}

Garcia-Bermejo, Maria L. ^{[4
,5
]}

Bosisio, Enrica ^{[6
]}

Xu, Qihe ^{[7
]}

Li, Huige ^{[8
]}

Dong, Xuebin ^{[9
]}

Simmonds, Monique S. J. ^{[10
]}

Carrara, Maria ^{[2
]}

Tejedor, Noelia ^{[5
]}

Lucio-Cazana, Javier ^{[5
]}

Hylands, Peter J. ^{[1
]}

机构：

[1] Kings Coll London, Inst Pharmaceut Sci, London SE1 9NH, England

[2] Univ Padua, Dept Pharmacol & Anesthesiol, Padua, Italy

[3] Data Med, Padua, Italy

[4] IRYCIS, Dept Pathol, Madrid, Spain

[5] Univ Alcala de Henares, Dept Physiol, Sch Med, Madrid, Spain

[6] Univ Milan, Dept Pharmacol Sci, Milan, Italy

[7] Kings Coll London, Dept Renal Med, London WC2R 2LS, England

[8] Johannes Gutenberg Univ Mainz, Dept Pharmacol, D-6500 Mainz, Germany

[9] Kings Coll London, Div Cardiovasc, London WC2R 2LS, England

[10] Royal Bot Gardens, Richmond TW9 3AB, Surrey, England

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2012年 / 140卷 / 03期

关键词：

Genomics; Transcriptomics; Metabolomics; Metabonomics; Proteomics; Traditional Chinese medicine; Chinese herbal medicine; GENE-EXPRESSION PROFILES; CANCER-CELLS; METABOLOMICS; AUTHENTICATION; IDENTIFICATION; PROTEOMICS; EXTRACT; APOPTOSIS; FORMULA; DIFFERENTIATION;

D O I：

10.1016/j.jep.2012.01.055

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Omic techniques have become key tools in the development of systems biology. As the holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new tendencies in Western medicine towards personalised medicine require in-depth knowledge of mechanisms of action and active compounds, the use of omic techniques is crucial for understanding and interpretation of TCM development, especially in view of its expansion in Western countries. In this short review, omic applications in TCM research are reviewed which has allowed some speculation regarding future perspectives for these approaches in TCM modernisation and standardisation. Guidelines for good practice for the application of omics in TCM research are also proposed. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：535 / 544

页数：10

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