Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles

被引：88

作者：

Ahmed, Daniel ^{[1
]}

Chan, Chung Yu ^{[1
]}

Lin, Sz-Chin Steven ^{[1
]}

Muddana, Hari S. ^{[2
]}

Nama, Nitesh ^{[1
]}

Benkovic, Stephen J. ^{[3
]}

Huang, Tony Jun ^{[1
,2
]}

机构：

[1] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA

[2] Penn State Univ, Dept Bioengn, University Pk, PA 16802 USA

[3] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

LAB ON A CHIP | 2013年 / 13卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

ON-A-CHIP; MICROFLUIDIC CHANNEL; SINGLE; STIMULATION; DIFFERENTIATION; CHEMOTAXIS; RESPONSES; DYNAMICS; CELLS; LAB;

D O I：

10.1039/c2lc40923b

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a novel concept of generating both static and pulsatile chemical gradients using acoustically activated bubbles designed in a ladder-like arrangement. Furthermore, by regulating the amplitude of the bubble oscillation, we demonstrate that the chemical gradient profiles can be effectively tuned.

引用

页码：328 / 331

页数：4

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