Photoluminescent Silicon Nanocrystal-Based Multifunctional Carrier for pH-Regulated Drug Delivery

被引：46

作者：

Xu, Zhigang ^{[1
]}

Wang, Dongdong ^{[1
]}

Guan, Min ^{[1
,4
]}

Liu, Xiaoyan ^{[1
]}

Yang, Yanjie ^{[1
]}

Wei, Dongfeng ^{[2
]}

Zhao, Chunyan ^{[3
]}

Zhang, Haixia ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Sch Basic Med Sci, Lanzhou 730000, Peoples R China

[3] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

[4] Sinopec Beijing Chem Ind Inst, Yanshan Branch, Beijing 102500, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2012年 / 4卷 / 07期

基金：

中国国家自然科学基金;

关键词：

nanocrystalline silicon; cytotoxicity; controlled release; drug delivery; LUMINESCENT POROUS SILICON; QUANTUM DOTS; HYBRID NANOGELS; NANOPARTICLES; CYTOTOXICITY; SIZE; INTEGRATION; ACID);

D O I：

10.1021/am300877v

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A core-shell structured multifunctional carrier with nanocrystalline silicon (ncSi) as the core and a water-soluble block copolymer as the shell based on a poly(methacrylic acid) (PMAA) inner shell and polyethylene glycol (MPEG) outer shell (ncSi-MPM) was synthesized for drug delivery. The morphology, composition, and properties of the resulting ncSi-MPM were determined by comprehensive multianalytical characterization, including H-1 NMR. spectroscopy, FTIR spectroscopy, XPS spectroscopy, TEM, DLS, and fluorescence spectroscopy analyses. The size of the resulting ncSi-MPM nanocarriers ranged from 40 to 110 nm under a simulated physiological environment. The loading efficiency of model drug doxorubicin (DOX) was approximately 6.1-74 wt % for ncSi-MPM and the drug release was pH controlled. Cytotoxicity studies demonstrated that DOX-loaded ncSi-MPM showed high anticancer activity against Hela cells. Hemolysis percentages (<2%) of ncSi-MPM were within the scope of safe values. Fluorescent imaging studies showed that the nanocarriers could be used as a tracker at the cellular level. Integration of the above functional components may result in ncSi-MPM becoming a promising multifunctional carrier for drug delivery and biomedical applications.

引用

页码：3424 / 3431

页数：8

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