Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula

被引：31

作者：

Huang, Zhen ^{[1
]}

Mao, Qing-Qiu ^{[2
]}

Zhong, Xiao-Ming ^{[1
]}

Li, Zhao-Yi ^{[1
]}

Qiu, Feng-Mei ^{[1
]}

Ip, Siu-Po ^{[2
]}

机构：

[1] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China

[2] Chinese Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2012年 / 2012卷

关键词：

CHRONIC MILD STRESS; CHRONIC UNPREDICTABLE STRESS; MAJOR DEPRESSION; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; PEONY GLYCOSIDES; OXIDATIVE DAMAGE; ETHANOL EXTRACT; CURCUMA-LONGA; MICE;

D O I：

10.1155/2012/173565

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Danggui-Shaoyao-San (DSS), a famous Chinese herbal formula, has been widely used in the treatment of various diseases. Previous studies have shown that DSS produces antidepressant-like effect in rodents. This study aims to investigate the mechanism(s) underlying the antidepressant-like action of DDS. The results showed that DSS treatment significantly antagonized reserpine-induced ptosis in mice. In addition, DSS treatment significantly increased sucrose consumption in chronic unpredictable stress- (CUS-) treated mice. DSS treatment also markedly attenuated CUS-induced decreases in noradrenaline and dopamine concentrations in mouse brain. Furthermore, DSS treatment significantly reversed CUS-induced increase in serum malondialdehyde (MDA) content and decrease in serum superoxide dismutase (SOD) activity in mice. The results suggest that the antidepressant-like activity of DSS is probably mediated by the modulation of central monoamine neurotransmitter systems and the reduction of oxidative stress.

引用

页数：7

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