Paradigm of negative feedback via long-loop in the striatal dopamine release modulation in the rat

Introduction. The basal ganglia include the striatum, globus pallidus, the substantia nigra pars compacta and pars reticulata. The striatum receives afferent input from the substantia nigra pars compacta. The principal neurons of the striatum are medium spiny neurons, that express high levels of D-1 and D-2 receptors. Aims. This review deals about the aspects underlying to the negative feedback via long-loop in the striatal dopamine release modulation in the rat. Also, the motor function in dopamine receptor knock-out mice is discussed. Development and conclusions. The intrastriatal infusion and systemic injection of dopamine receptor agonists and antagonists may regulate the striatal dopamine release and induce changes in motor function. Disruption of the D-1 and D-2 gene shown that the motor function is controled by D-1 and D-2 receptors. The study of the long-loop negative feedback may contribute to our understanding in the physiolcgy and dysfunction of basal ganglia.