Early and late onset Alzheimer's disease patients have distinct patterns of white matter damage

被引：54

作者：

Canu, Elisa ^{[1
]}

Frisoni, Giovanni B. ^{[2
]}

Agosta, Federica ^{[1
]}

Pievani, Michela ^{[1
,2
]}

Bonetti, Matteo ^{[3
]}

Filippi, Massimo ^{[1
]}

机构：

[1] Ist Sci San Raffaele, Div Neurosci, Inst Expt Neurol, Neuroimaging Res Unit, I-20132 Milan, Italy

[2] Ctr San Giovanni Dio Fatebenefratelli, IRCCS, Brescia, Italy

[3] Ist Clin Citta Brescia, Serv Neuroradiol, Brescia, Italy

来源：

NEUROBIOLOGY OF AGING | 2012年 / 33卷 / 06期

关键词：

Alzheimer's disease; Early onset; White matter; Atrophy; VBM; CEREBRAL GLUCOSE-METABOLISM; APOLIPOPROTEIN-E EPSILON-4; APOE EPSILON-4; SENILE-DEMENTIA; BRAIN ATROPHY; CORPUS-CALLOSUM; TRACT INTEGRITY; IN-VIVO; AGE; VULNERABILITY;

D O I：

10.1016/j.neurobiolaging.2010.09.021

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We investigated patterns of white matter (WM) loss in 18 early onset (EO) and 24 late onset (LO) Alzheimer's disease (AD) patients compared with 42 healthy controls (HC), and explored relationships of WM atrophy and apolipoprotein E (ApoE) genotype. Subjects underwent magnetic resonance imaging (MRI). Patterns of WM were assessed using voxel-based morphometry. Compared with healthy controls, LOAD patients had a selective parahippocampal WM loss, while EOAD patients experienced a more widespread pattern of posterior WM atrophy. The distinct regional distribution of WM atrophy reflected the topography of gray matter (GM) loss. ApoE epsilon 4 status was associated with a greater parahippocampal WM loss in both AD groups. The greater WM atrophy in EOAD than LOAD fits with the evidence that EOAD is a more aggressive form of the disease. The ApoE epsilon 4 effect on WM damage in AD is restricted to specific WM regions and does not seem to be related to age of onset. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1023 / 1033

页数：11

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