A traceless linker approach to the solid phase synthesis of substituted guanidines utilizing a novel acyl isothiocyanate resin

被引：43

作者：

Wilson, LJ ^{[1
]}

Klopfenstein, SR ^{[1
]}

Li, M ^{[1
]}

机构：

[1] Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期

关键词：

solid phase synthesis; guanidines; EDC; combinatorial chemistry; isothiocyanate;

D O I：

10.1016/S0040-4039(99)00663-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solid phase synthesis of a series of substituted guanidines based on a novel acyl isothiocyanate resin is presented. This method provides both mono and disubstituted guanidines with a variety of sterically demanding and/or electron withdrawing substituents in good purities and yields. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3999 / 4002

页数：4

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