Redundant function of retinoic acid receptor isoforms in leukemogenesis unravels a prominent function of genome topology and architecture in the selection of mutagenic events in cancer

被引:15
作者
Marinelli, A. [1 ]
Bossi, D. [2 ]
Pelicci, P. G. [2 ,3 ]
Minucci, S. [1 ,2 ]
机构
[1] Univ Milan, Dept Biomol Sci & Biotechnol, Milan, Italy
[2] European Inst Oncol, Dept Expt Oncol, Milan, Italy
[3] Univ Milan, Dept Med Surg & Odontoiatry, Milan, Italy
关键词
ACUTE PROMYELOCYTIC LEUKEMIA; RAR-ALPHA; GENETICS; GAMMA;
D O I
10.1038/leu.2008.205
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:417 / 419
页数:4
相关论文
共 8 条
[1]   A decade of molecular biology of retinoic acid receptors [J].
Chambon, P .
FASEB JOURNAL, 1996, 10 (09) :940-954
[2]  
GRIGNANI F, 1994, BLOOD, V83, P10
[3]   Molecular genetics of acute promyelocytic leukemia [J].
Lin, RJ ;
Egan, DA ;
Evans, RM .
TRENDS IN GENETICS, 1999, 15 (05) :179-184
[4]   A redundant oncogenic potential of the retinoic receptor (RAR) α, β and γ isoforms in acute promyelocytic leukemia [J].
Marinelli, A. ;
Bossi, D. ;
Pelicci, P. G. ;
Minucci, S. .
LEUKEMIA, 2007, 21 (04) :647-650
[5]   Deconstructing a disease:: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia [J].
Melnick, A ;
Licht, JD .
BLOOD, 1999, 93 (10) :3167-3215
[6]   PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors [J].
Minucci, S ;
Monestiroli, S ;
Giavara, S ;
Ronzoni, S ;
Marchesi, F ;
Insinga, A ;
Diverio, D ;
Gasparini, P ;
Capillo, M ;
Colombo, E ;
Matteucci, C ;
Contegno, F ;
Lo-Coco-, F ;
Scanziani, E ;
Gobbi, A ;
Pelicci, PG .
BLOOD, 2002, 100 (08) :2989-2995
[7]   RARγ is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation [J].
Purton, Louise E. ;
Dworkin, Sebastian ;
Olsen, Gemma Haines ;
Walkley, Carl R. ;
Fabb, Stewart A. ;
Collins, Steven J. ;
Chambon, Pierre .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (05) :1283-1293
[8]   High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expression [J].
Westervelt, P ;
Lane, AA ;
Pollock, JL ;
Oldfather, K ;
Holt, MS ;
Zimonjic, DB ;
Popescu, NC ;
DiPersio, JF ;
Ley, TJ .
BLOOD, 2003, 102 (05) :1857-1865