Hemophagocytic Lymphohistiocytosis: A Dangerous Intruder in Pediatric Acute Lymphoblastic Leukemia

被引：5
作者：
Martinez-Romera, Isabel [1 ]
Villa, Marta [1 ]
Areal, Pilar [1 ]
Rodrigo, Esther [2 ]
Herrero, Blanca [1 ]
Lopez-Ibor, Blanca [1 ]
机构：
[1] Madrid Monteprincipe Hosp, Pediat Hematol & Oncol Unit, Madrid, Spain
[2] HM Grp, Hemathol & Hemotherapy Dept, Madrid, Spain
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2018年 / 40卷 / 02期
关键词：
hemophagocytic limphohistiocytosis; acute lymphoblastic leukemia; hemophagocytosis; infection; immune system; MAINTENANCE TREATMENT; CHILDREN; ADULTS; THERAPY; HLH;
D O I：
10.1097/MPH.0000000000000932
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hemophagocytic lymphohistiocytosis (HLH) is a condition caused by a pathologic immune activation, which is responsible for its signs and symptoms. It may also appear as a secondary process caused by malignancy. Developing HLH during treatment for acute lymphoblastic leukemia (ALL) is extremely uncommon, but underdiagnosis may be fatal. Two patients with ALL on chemotherapy maintenance treatment who developed HLH triggered by infection are presented here. We emphasize the importance of being aware of this condition when a patient with ALL in complete remission presents with unexplained hepatomegaly, cytopenia, and fever. Early diagnosis and treatment may be lifesaving.
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收藏
页码：E108 / E110
页数：3
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