Reduced Graphene Oxide Functionalized with a Luminescent Rare-Earth Complex for the Tracking and Photothermal Killing of Drug-Resistant Bacteria

被引：70
作者：
Yang, Xinjian [1 ,2 ,3 ]
Li, Zhenhua [1 ,2 ,3 ]
Ju, Enguo [1 ,2 ,3 ]
Ren, Jinsong [1 ,2 ]
Qu, Xiaogang [1 ,2 ]
机构：
[1] Acad Sinica, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Peoples R China
[2] Acad Sinica, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 02期
基金：
中国国家自然科学基金;
关键词：
imaging; luminescent complexes; rare-earth complexes; photothermal killing; reduced graphene oxide; BIOFUNCTIONAL MAGNETIC NANOPARTICLES; NEAR-INFRARED ABSORBENCY; GRAM-NEGATIVE BACTERIA; CANCER-THERAPY; CARBON NANOTUBES; AGENTS; RELEASE; LIGHT; HYPERTHERMIA; PROBES;
D O I：
10.1002/chem.201303964
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An antibacterial platform based on multifunctional reduced graphene oxide (rGO) that is responsive to near-infrared (NIR) light has been constructed. By introducing a luminescent Eu3+ complex and vancomycin for bacteria tracking into one system, this platform could specifically recognize and light up bacteria. Antibacterial activity of this nanoscale construction under NIR illumination was investigated. Upon illumination with NIR light, this nanoscale architecture generates great heat locally, resulting in the death of drug-resistant bacteria. These results indicate that the ability of this nanoscale platform to kill drug-resistant bacteria has great potential for clinical pathogenic bacteria diagnosis and treatment.
引用
收藏
页码：394 / 398
页数：5
相关论文
共 39 条
  • [1] Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria
    Akhavan, Omid
    Ghaderi, Elham
    [J]. ACS NANO, 2010, 4 (10) : 5731 - 5736
  • [2] Resistance to antibiotics: Are we in the post-antibiotic era?
    Alanis, AJ
    [J]. ARCHIVES OF MEDICAL RESEARCH, 2005, 36 (06) : 697 - 705
  • [3] Dendrimer-Based Multivalent Vancomycin Nanoplatform for Targeting the Drug-Resistant Bacterial Surface
    Choi, Seok Ki
    Myc, Andrzej
    Silpe, Justin Ezekiel
    Sumit, Madhuresh
    Wong, Pamela Tinmoi
    McCarthy, Kelly
    Desai, Ankur M.
    Thomas, Thommey P.
    Kotlyar, Alina
    Holl, Mark M. Banaszak
    Orr, Bradford G.
    Baker, James R., Jr.
    [J]. ACS NANO, 2013, 7 (01) : 214 - 228
  • [4] The therapeutic efficacy of CdTe and CdSe quantum dots for photothermal cancer therapy
    Chu, Maoquan
    Pan, Xiaojing
    Zhang, Ding
    Wu, Qiang
    Peng, Jinliang
    Hai, Wangxi
    [J]. BIOMATERIALS, 2012, 33 (29) : 7071 - 7083
  • [5] Luminescent Tags on Fullerenes: Eu3+ Complexes with Pendant Fullerenes
    Fuchsbatter, Anita
    Troshina, Olesya A.
    Troshin, Pavel A.
    Koeppe, Robert
    Lyubovskaya, Rimma N.
    Sariciftci, Niyazi Serdar
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2008, 18 (18) : 2808 - 2814
  • [6] Combining fluorescent probes and biofunctional magnetic nanoparticles for rapid detection of bacteria in human blood
    Gao, Jinhao
    Li, Lihua
    Ho, Pak-Leung
    Mak, Gannon C.
    Gu, Hongwei
    Xu, Bing
    [J]. ADVANCED MATERIALS, 2006, 18 (23) : 3145 - +
  • [7] Using biofunctional magnetic nanoparticles to capture vancomycin-resistant enterococci and other gram-positive bacteria at ultralow concentration
    Gu, HW
    Ho, PL
    Tsang, KWT
    Wang, L
    Xu, B
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (51) : 15702 - 15703
  • [8] Graphene-Based Antibacterial Paper
    Hu, Wenbing
    Peng, Cheng
    Luo, Weijie
    Lv, Min
    Li, Xiaoming
    Li, Di
    Huang, Qing
    Fan, Chunhai
    [J]. ACS NANO, 2010, 4 (07) : 4317 - 4323
  • [9] Multifunctional Fe3O4@Au Nanoeggs as Photothermal Agents for Selective Killing of Nosocomial and Antibiotic-Resistant Bacteria
    Huang, Wei-Chieh
    Tsai, Pei-Jane
    Chen, Yu-Chie
    [J]. SMALL, 2009, 5 (01) : 51 - 56
  • [10] Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
    Huang, Xiaohuo
    Neretina, Svetiana
    El-Sayed, Mostafa A.
    [J]. ADVANCED MATERIALS, 2009, 21 (48) : 4880 - 4910
1234