Synthesis and cytotoxic activity of salicyloyl hydrazone derivatives

被引：0

作者：

Qiu, Xiaoyang ^{[1
]}

Shi, An-Ran ^{[2
]}

Zhang, Xiaoli ^{[1
]}

机构：

[1] Shangqiu Normal Coll, Dept Chem, Shangqiu 476000, Peoples R China

[2] Nanjing Univ Sci & Technol, Coll Chem & Chem Engn, Nanjing 210016, Jiangsu, Peoples R China

来源：

CHINA FUNCTIONAL MATERIALS TECHNOLOGY AND INDUSTRY FORUM | 2013年 / 320卷

关键词：

salicyloyl hydrazone derivatives; cytotoxic activity; structure-activity relationships; IN-VITRO; ANTIMYCOBACTERIAL ACTIVITY; TUBERCULOSIS;

D O I：

10.4028/www.scientific.net/AMM.320.522

中图分类号：

TH [机械、仪表工业];

学科分类号：

0802 ;

摘要：

Three salicyloyl hydrazone derivatives (compounds 1-3) were prepared by reacting salicyloyl hydrazine with substituted formaldehydes. Their structures were characterized by melting point, 1H-NMR, ESI-MS and elemental analyses. The cytotoxic activity of compounds 1-3 was evaluated in vitro against Hela cells (human cervical cancer cells). The results revealed that all the compounds showed cytotoxic activity, with IC50 values lower than 15 mu M.

引用

页码：522 / +

页数：3

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