New 1,2-Dihydropyridine-Based Fluorophores and Their Applications as Fluorescent Probes

被引：11

作者：

Jamsheena, Vellekkatt ^{[1
]}

Mishra, Rakesh K. ^{[1
]}

Veena, Kollery S. ^{[1
]}

Sini, Suresh ^{[2
]}

Jayamurthy, Purushothaman ^{[2
]}

Lankalapalli, Ravi S. ^{[1
]}

机构：

[1] Acad Sci & Innovat Res AcSIR, Chem Sci & Technol Div, Thiruvananthapuram 695019, Kerala, India

[2] CSIR Natl Inst Interdisciplinary Sci & Technol, Acad Sci & Innovat Res AcSIR, Agroproc & Technol Div, Thiruvananthapuram 695019, Kerala, India

来源：

ACS OMEGA | 2018年 / 3卷 / 01期

关键词：

HEPATOCELLULAR-CARCINOMA; SELECTIVE DETECTION; ELECTRON; PTP1B;

D O I：

10.1021/acsomega.7b01835

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New 1,2-dihydropyridine (1,2-DHP)-based fluorophores 1a-1h were designed and synthesized by a one-pot four-component condensation reaction using dienaminodioate, aldehydes, and an in situ-generated hydrazone mediated by trifluoroacetic acid. The photophysical properties of 1,2-DHPs were studied in detail, and a few of them exhibited selective mitochondrial staining ability in HeLa cell lines (cervical cancer cells). A detailed photophysical investigation led to the design of 1,2-DHP 1h as an optimal fluorophore suitable for its potential application as a small molecule probe in the aqueous medium. Also, 1,2-DHP 1h exhibited sixfold enhanced emission intensity than its phosphorylated analogue 1h' in the long wavelength region (lambda(em) approximate to 600 nm), which makes 1,2-DHP 1h' meet the requirement as a bioprobe for protein tyrosine phosphatases, shown in L6 muscle cell lysate.

引用

页码：856 / 862

页数：7

共 31 条

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