Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

被引：22

作者：

Tao, Min-fang ^{[1
]}

Zhang, Zeng ^{[2
,3
]}

Ke, Yao-hua ^{[2
]}

He, Jin-wei ^{[2
]}

Fu, Wen-zhen ^{[2
]}

Zhang, Chang-qing ^{[3
]}

Zhang, Zhen-lin ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Gynecol & Obstet, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China

[2] Shanghai Jiao Tong Univ, Dept Osteoporosis & Bone Dis, Metabol Bone Dis & Genet Res Unit, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Orthoped Surg, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 2013年 / 34卷 / 08期

基金：

中国国家自然科学基金;

关键词：

vitamin D; 25-hydroxyvitamin D; type; 2; diabetes; beta-cell function; insulin resistance; female; VITAMIN-D DEFICIENCY; FASTING PLASMA-GLUCOSE; DWELLING OLDER-ADULTS; METABOLIC SYNDROME; PARATHYROID-HORMONE; OBESE CHILDREN; D INSUFFICIENCY; RAT PANCREAS; SECRETION; RISK;

D O I：

10.1038/aps.2013.13

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aim: To assess associations of the serum level of 25-hydroxyvitamin D with insulin resistance and beta-cell function in a healthy Chinese female population. Methods: This cross-sectional study included 1382 female participants free of type 2 diabetes who were recruited in Shanghai. Blood samples were collected within a winter season and the serum levels of 25-hydroxyvitamin D, fasting plasma glucose and insulin, and other biochemical parameters were determined. Insulin resistance and beta-cell function were assessed using the homeostasis model assessments of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B), respectively. Results: Multiple linear regression analyses adjusted for age, parathyroid hormone, Ca2+ and BMI revealed that independent inverse associations existed between the serum level of 25-hydroxyvitamin D and HOMA-IR (P<0.001) and between the serum level of 25-hydroxyvitamin D and HOMA-B (P=0.001). Conclusion: Serum vitamin D level is significantly and independently associated with insulin resistance and beta-cell function in a healthy Chinese female population.

引用

页码：1070 / 1074

页数：5

共 38 条

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