Base-pairing systems related to TNA:: α-threofuranosyl oligonucleotides containing phosphoramidate linkages

被引：38
作者：
Wu, XL
Guntha, S
Ferencic, M
Krishnamurthy, R
Eschenmoser, A
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Swiss Fed Inst Technol, Organ Chem Lab, CH-8093 Zurich, Switzerland
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 08期
关键词：
D O I：
10.1021/ol020015x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHIC] (3'NH)- and (2'NH)-TNA, two isomeric phosphoramidate analogues of TNA (alpha-threofuranosyl-(3'-->2') oligonucleotides), are shown to be efficient Watson-Crick base-pairing systems and to undergo intersystem cross-pairing with TNA, RNA, and DNA.
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收藏
页码：1279 / 1282
页数：4
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