Bioactive carbazole alkaloids from Murraya koenigii (L.) Spreng

被引：53
作者：
Ma, Qinge
Tian, Jin
Yang, Jianbo
Wang, Aiguo
Ji, Tengfei
Wang, Yangai
Su, Yalun [1 ]
机构：
[1] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
FITOTERAPIA | 2013年 / 87卷
关键词：
Murraya koenigii; Carbazole alkaloid; Hepatoprotective activity; PTP1B inhibitory activity; GLYCOSIDES;
D O I：
10.1016/j.fitote.2013.03.003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new carbazole alkaloids (1-4) and fourteen known carbazole alkaloids (5-18) were isolated from Murraya koenigii. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 4, 6, 16, and 17 (10 mu M) had moderate hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage. Compounds 11, 12 and 18 showed significant PTP1B inhibitory activity with IC50 values of 1.773, 1.875 and 2.286 mu M, respectively. (c) 2013 Elsevier B.V. All rights reserved.
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页码：1 / 6
页数：6
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