What Is the Role of Brain Stimulation Therapies in the Treatment of Depression?

被引：12

作者：

Blumberger, Daniel M. ^{[1
,2
]}

Mulsant, Benoit H. ^{[1
]}

Daskalakis, Zafiris J. ^{[1
,2
]}

机构：

[1] Univ Toronto, Campbell Family Res Inst, Ctr Addict & Mental Hlth, Dept Psychiat, Toronto, ON M6J 1H4, Canada

[2] Temerty Ctr Therapeut Brain Intervent, Toronto, ON, Canada

来源：

CURRENT PSYCHIATRY REPORTS | 2013年 / 15卷 / 07期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

Brain stimulation; Major depression; MDD; Treatment-resistant depression; TRD; Transcranial direct current stimulation; tDCS; Repetitive transcranial magnetic stimulation; rTMS; Magnetic seizure therapy; MST; Vagus nerve stimulation; VNS; Deep brain stimulation; DBS; Mood disorders; Psychiatry; TRANSCRANIAL MAGNETIC STIMULATION; VAGUS NERVE-STIMULATION; TREATMENT-RESISTANT DEPRESSION; UNILATERAL ELECTROCONVULSIVE-THERAPY; CANMAT CLINICAL GUIDELINES; SEIZURE THERAPY; MAJOR DEPRESSION; DOUBLE-BLIND; CONTROLLED-TRIAL; ELECTRODE PLACEMENT;

D O I：

10.1007/s11920-013-0368-1

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Brain stimulation therapies have demonstrated efficacy in the treatment of depression and treatment-resistant depression (TRD). Non-invasive brain stimulation in the treatment of depression has grown substantially due to their favorable adverse effect profiles. The role of transcranial direct current stimulation in TRD is unclear, but emerging data suggests that it may be an effective add-on treatment. Repetitive transcranial magnetic stimulation has demonstrated efficacy in TRD that is supported by several multicenter randomized controlled trials. Though, vagus nerve stimulation has been found to be effective in some studies, sham controlled studies were equivocal. Electroconvulsive therapy (ECT) is a well-established brain stimulation treatment for severe depression and TRD, yet stigma and cognitive adverse effects limit its wider use. Magnetic seizure therapy has a more favorable cognitive adverse effect profile; however, equivalent efficacy to ECT needs to be established. Deep brain stimulation may play a role in severe TRD and controlled trials are now underway.

引用

页数：10

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