DNA mismatch repair in mammals: Role in disease and meiosis

被引：36

作者：

Arnheim, N ^{[1
]}

Shibata, D ^{[1
]}

机构：

[1] UNIV SO CALIF,SCH MED,DEPT PATHOL,LOS ANGELES,CA 90033

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0959-437X(97)80150-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The understanding of mammalian mismatch repair (MMR) gene function has been accelerated as a result of progress on several fronts. First, the biochemical analysis of MMR has been advanced by the production of purified human MMR proteins which will eventually allow reconstitution of MMR activity in vitro. Second, a wealth of clinical studies on colon cancer patients have begun to allow correlations to be made among MMR mutations, tumor types, therapeutic approaches and clinical outcomes. Finally, new unexpected meiotic phenotypes have been associated with mutations in certain mouse MMR genes.

引用

页码：364 / 370

页数：7

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