Time course production of indole alkaloids by an endophytic strain of Penicillium brasilianum cultivated in rice

被引：19

作者：

Fill, Taicia Pacheco ^{[1
]}

Rodrigues Asenha, Heloisa Briganti ^{[1
]}

Marques, Anna Silvia ^{[2
]}

Ferreira, Antonio Gilberto ^{[1
]}

Rodrigues-Fo, Edson ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Paulo, Brazil

[2] Appl Biosyst Inc, Sao Paulo, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

Penicillium; endophytic; tremorgenic indole alkaloid; verruculogen; biosynthesis; VERRUCULOGEN; BIOSYNTHESIS; MEROTERPENES; TR-2;

D O I：

10.1080/14786419.2012.701210

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

During our studies concerning endophytic fungi, two indole alkaloids were co-produced with verruculogen by Penicillium brasilianum isolated from Melia azedarach (Meliaceae). The compounds were isolated by the use of combined chromatographic procedures and identified by physical methods, mainly 1D- and 2D-NMR experiments. This article also describes the production of verruculogen TR-2, first described for this species of Penicillium, and a verruculogen TR-2C-11 epimer, that is a novel fungal natural product. The kinetic production of verruculogen and verruculogen TR-2 produced by P. brasilianum were evaluated in order to understand the involvement of verruculogen TR-2 in verruculogen biosynthesis.

引用

页码：967 / 974

页数：8

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