Highly sensitive detection of urinary cadmium to assess personal exposure

被引：13

作者：

Argun, Avni A. ^{[1
]}

Banks, Ashley M. ^{[1
]}

Merlen, Gwendolynne ^{[1
]}

Tempelman, Linda A. ^{[1
]}

Becker, Michael F. ^{[2
]}

Schuelke, Thomas ^{[2
]}

Dweik, Badawi M. ^{[1
]}

机构：

[1] Giner Inc, Newton, MA 02466 USA

[2] Fraunhofer USA CCL, E Lansing, MI 48824 USA

来源：

ANALYTICA CHIMICA ACTA | 2013年 / 773卷

基金：

美国国家卫生研究院;

关键词：

Boron-Doped Diamond (BDD); Ultramicroelectrode array; Electrochemical sensors; Urinary trace metal detection; Cadmium; Differential pulse stripping voltammetry (DPSV); BORON-DOPED DIAMOND; ANODIC-STRIPPING VOLTAMMETRY; ELECTROCHEMICAL ANALYSIS; ULTRAMICROELECTRODE ARRAYS; MICROELECTRODE ARRAYS; THIN-FILM; ELECTRODES; WATER; FABRICATION; SAMPLES;

D O I：

10.1016/j.aca.2013.02.034

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A series of Boron-Doped Diamond (BDD) ultrarnicroelectrode arrays were fabricated and investigated for their performance as electrochemical sensors to detect trace level metals such as cadmium. The steady-state diffusion behavior of these sensors was validated using cyclic voltammetry followed by electrochemical detection of cadmium in water and in human urine to demonstrate high sensitivity (>200 mu A ppb(-1) cm(-2)) and low background current (<4 nA). When an array of ultramicroelectrodes was positioned with optimal spacing, these BDD sensors showed a sigmoidal diffusion behavior. They also demonstrated high accuracy with linear dose dependence for quantification of cadmium in a certified reference river water sample from the U.S. National Institute of Standards and Technology (NIST) as well as in a human urine sample spiked with 0.25-1 ppb cadmium. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：45 / 51

页数：7

共 34 条

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[Anonymous], 2001, ELECTROCHEMICAL METH

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