Assembly system of direct modified superparamagnetic iron oxide nanoparticles for target-specific MRI contrast agents

被引：24
|
作者：
Tanaka, Kazuo [1 ]
Kitamura, Narufumi [1 ]
Morita, Masahito [2 ]
Inubushi, Toshiro [2 ]
Chujo, Yoshiki [1 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Polymer Chem, Nishikyo Ku, Kyoto 6158510, Japan
[2] Shiga Univ Med Sci, Biomed MR Sci Ctr, Setatsukinowa, Otsu 5202192, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 20期
关键词：
MRI; contrast agent; SPIO; nanoparticle; aptamer; assembly;
D O I：
10.1016/j.bmcl.2008.09.035
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We report the direct modification of SPIOs with a biomolecule and the target-specific assembly system of these modified SPIOs for using MRI contrast agents. The transverse relaxation rate of the aqueous solutions containing the modified SPIOs was altered by the dispersion state. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5463 / 5465
页数：3
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