Bacterial Cell Division Regulation by Ser/Thr Kinases: A Structural Perspective

被引：49
作者：
Ruggiero, Alessia [1 ]
De Simone, Paola [1 ]
Smaldone, Giovanni [1 ,2 ]
Squeglia, Flavia [1 ,2 ]
Berisio, Rita [1 ]
机构：
[1] CNR, Inst Biostruct & Bioimaging, I-80134 Naples, Italy
[2] Univ Naples Federico II, Dept Chem, I-80134 Naples, Italy
来源：
CURRENT PROTEIN & PEPTIDE SCIENCE | 2012年 / 13卷 / 08期
关键词：
Cell division; structure; phosphorylation; peptidoglycan; SERINE/THREONINE PROTEIN-KINASE; MYCOBACTERIUM-TUBERCULOSIS; STREPTOCOCCUS-PNEUMONIAE; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; ACTIVATION MECHANISM; ALLOSTERIC ACTIVATION; STAPHYLOCOCCUS-AUREUS; WALL HYDROLASE; Z-RING;
D O I：
10.2174/138920312804871201
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent genetic, biochemical and structural studies have established that eukaryotic-like Ser/Thr protein-kinases are critical mediators of developmental changes and host pathogen interactions in bacteria. Although with lower abundance compared to their homologues from eukaryotes, Ser/Thr protein-kinases are widespread in gram-positive bacteria. These data underline a key role of reversible Ser/Thr phosphorylation in bacterial physiology and virulence. Numerous studies have revealed how phosphorylation/dephosphorylation of Ser/Thr protein-kinases governs cell division and cell wall biosynthesis and that Ser/Thr protein kinases are responsible for distinct phenotypes, dependent on different environmental signals. In this review we discuss the current understandings of Ser/Thr protein-kinases functional processes based on structural data.
引用
收藏
页码：756 / 766
页数：11
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