Occludin dislocation in brain capillary endothelium of rats with bile duct ligation induced cholestasis

被引：3

作者：

Mavrakis, Adamantios G. ^{[1
]}

Havaki, Sophia ^{[2
]}

Marinos, Evangelos ^{[2
]}

Chroni, Elisabeth ^{[3
]}

Konstantinou, Dimitris ^{[1
]}

机构：

[1] Univ Patras, Sch Med, Dept Neurosurg, GR-26110 Patras, Greece

[2] Univ Athens, Sch Med, Lab Histol & Embryol, GR-11527 Athens, Greece

[3] Univ Patras, Sch Med, Dept Neurol, GR-26110 Patras, Greece

来源：

NEUROSCIENCE LETTERS | 2012年 / 528卷 / 02期

关键词：

Tight junction; Brain endothelium; Electron microscopy; Occludin relocalization; Bile duct ligation; Obstructive cholestasis; HEPATIC-ENCEPHALOPATHY; OBSTRUCTIVE-JAUNDICE; OXIDATIVE STRESS; TIGHT JUNCTIONS; OXIDATIVE/NITROSATIVE STRESS; WHITE-MATTER; BARRIER; PATHOPHYSIOLOGY; HYPERAMMONEMIA; PERMEABILITY;

D O I：

10.1016/j.neulet.2012.08.066

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study used a rat model with bile duct ligation to examine the effect of cholestasis, to the localization of occludin in brain capillary endothelium by means of electronic microscopy. The results demonstrated a dislocation of occludin away from the tight junction sites of brain endothelial cells. A significant increase of the occludin-interendothelial cleft distance was demonstrated in the midbrain and the cerebellum samples but not in the frontal cortex, compared to the control group samples. These findings imply a brain region selective derangement of occludin in response to liver disease. (C) 2012 Published by Elsevier Ireland Ltd.

引用

页码：180 / 184

页数：5

共 27 条

[1] Regional differences in cerebral blood flow and cerebral ammonia metabolism in patients with cirrhosis [J].

Ahl, B ;

Weissenborn, K ;

van den Hoff, J ;

Fischer-Wasels, D ;

Köstler, H ;

Hecker, H ;

Burchert, W .

HEPATOLOGY, 2004, 40 (01) :73-79

[2] The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells [J].

Andras, Ibolya E. ;

Deli, Maria A. ;

Veszelka, Szilvia ;

Hayashi, Kentaro ;

Hennig, Bernhard ;

Toborek, Michal .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2007, 27 (08) :1431-1443

[3] Pathophysiology of increased intestinal permeability in obstructive jaundice [J].

Assimakopoulos, Stelios F. ;

Scopa, Chrisoula D. ;

Vagianos, Constantine E. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2007, 13 (48) :6458-6464

[4] Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy [J].

Bemeur, Chantal ;

Desjardins, Paul ;

Butterworth, Roger F. .

METABOLIC BRAIN DISEASE, 2010, 25 (01) :3-9

[5] Hyperammonemia Increases GABAergic Tone in the Cerebellum but Decreases It in the Rat Cortex [J].

Cauli, Omar ;

Mansouri, Mohammad T. ;

Agusti, Ana ;

Felipo, Vicente .

GASTROENTEROLOGY, 2009, 136 (04) :1359-1367

[6] Brain oxidative stress induced by obstructive jaundice in rats [J].

Chroni, E ;

Patsoukis, N ;

Karageorgos, N ;

Konstantinou, D ;

Georgiou, C .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2006, 65 (02) :193-198

[7] Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients [J].

Corbalán, R ;

Chatauret, N ;

Behrends, S ;

Butterworth, RF ;

Felipo, V .

HEPATOLOGY, 2002, 36 (05) :1155-1162

[8] Hepatocyte growth factor attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier and decreases in expression of tight junctional proteins in cerebral vessels [J].

Date, Ichiro ;

Takagi, Norio ;

Takagi, Keiko ;

Tanonaka, Kouichi ;

Funakoshi, Hiroshi ;

Matsumoto, Kunio ;

Nakamura, Toshikazu ;

Takeo, Satoshi .

NEUROSCIENCE LETTERS, 2006, 407 (02) :141-145

[9] Altered occludin expression in brain capillaries induced by obstructive jaundice in rats [J].

Faropoulos, Konstantinos ;

Chroni, Elisabeth ;

Assimakopoulos, Stelios F. ;

Mavrakis, Adamantios ;

Stamatopoulou, Vassiliki ;

Toumpeki, Chrisavgi ;

Drainas, Denis ;

Grintzalis, Konstantinos ;

Papapostolou, Ioannis ;

Georgiou, Christos D. ;

Konstantinou, Dimitris .

BRAIN RESEARCH, 2010, 1325 :121-127

[10] Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier [J].

Fiala, M ;

Liu, QN ;

Sayre, J ;

Pop, V ;

Brahmandam, V ;

Graves, MC ;

Vinters, HV .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2002, 32 (05) :360-371

← 1 2 3 →