共 29 条
Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells
被引:23
作者:

Wang, Fan
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机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China

Xia, Xiumei
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h-index: 0
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Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China

Wang, Jinling
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China

Sun, Qian
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h-index: 0
机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China

Luo, Jin
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China

Cheng, Bin
论文数: 0 引用数: 0
h-index: 0
机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China
机构:
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan 430030, Peoples R China
基金:
美国国家科学基金会;
关键词:
Hepatitis B virus;
Hepatocellular carcinoma;
Inhibitor Bcl-2;
Inhibitor P16;
Notch;
shRNA;
HEPATOCELLULAR-CARCINOMA;
TUMOR SUPPRESSION;
HUMAN LIVER;
CANCER;
GENE;
IDENTIFICATION;
EXPRESSION;
SURVIVAL;
HOMOLOG;
PATHWAY;
D O I:
10.1007/s10529-012-1048-7
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Hepatocellular carcinoma (HCC) is a malignant tumor and hepatitis B virus X protein (HBx) plays a crucial role in its pathogenesis. The Notch1 signaling pathway is involved in various malignant tumors including liver cancers and down-regulation of Notch-1 may exert anti-tumor effects. Here, we demonstrate that inhibition of Notch1 by plasmid-based shRNA suppresses growth of human hepatic cells transfected with HBx through G0/G1 cell cycle arrest and apoptosis inhibition, possibly linked to the promoted expression of cyclin-dependent kinase inhibitor, P16, and decreased expression of apoptosis inhibitor, Bcl-2. The anti-proliferative and pro-apoptotic effects of Notch1 shRNA in HBx-transformed L02 cell may be partly mediated by down-regulation of nuclear factor-kappaB (NF-kappa B) binding activities, demonstrating possible cross-talk between Notch-1 and NF-kappa B signaling pathways. The oncogene HBx may therefore induce malignant transformation of human hepatic cells via Notch1 pathway, indicating that Notch1 plays a crucial role in HBx-related liver cancer and could be an effective therapeutic target for HCC.
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页码:29 / 37
页数:9
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