Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

被引：22

作者：

Duell, Eric J. ^{[1
]}

Travier, Noemie ^{[1
]}

Lujan-Barroso, Leila ^{[1
]}

Dossus, Laure ^{[2
]}

Boutron-Ruault, Marie-Christine ^{[2
]}

Clavel-Chapelon, Francoise ^{[2
]}

Tumino, Rosario ^{[3
,4
]}

Masala, Giovanna ^{[5
]}

Krogh, Vittorio ^{[6
]}

Panico, Salvatore ^{[7
]}

Ricceri, Fulvio ^{[8
]}

Luisa Redondo, Maria

Dorronsoro, Miren ^{[9
,10
]}

Molina-Montes, Esther ^{[11
]}

Huerta, Jose M. ^{[12
]}

Barricarte, Aurelio ^{[13
]}

Khaw, Kay-Tee ^{[14
]}

Wareham, Nick J. ^{[15
]}

Allen, Naomi E. ^{[16
]}

Travis, Ruth ^{[16
]}

Siersema, Peter D. ^{[17
]}

Peeters, Petra H. M. ^{[18
,19
]}

Trichopoulou, Antonia ^{[20
,21
]}

Fragogeorgi, Eirini ^{[21
]}

Oikonomou, Eleni ^{[20
]}

Boeing, Heiner ^{[22
]}

Schuetze, Madlen ^{[22
]}

Canzian, Federico ^{[23
]}

Lukanova, Annekatrin ^{[24
]}

Tjonneland, Anne ^{[25
]}

Roswall, Nina ^{[26
]}

Overvad, Kim ^{[27
]}

Weiderpass, Elisabete ^{[28
]}

Gram, Inger Torhild ^{[28
]}

Lund, Eiliv ^{[28
]}

Lindkvist, Bjorn ^{[29
]}

Johansen, Dorthe ^{[30
]}

Ye, Weimin ^{[31
,32
]}

Sund, Malin ^{[33
,34
,35
]}

Fedirko, Veronika ^{[36
]}

Jenab, Mazda ^{[36
]}

Michaud, Dominique S. ^{[37
]}

Riboli, Elio ^{[37
]}

Bueno-de-Mesquita, H. Bas ^{[17
,38
]}

机构：

[1] Bellvitge Biomed Res Inst IDIBELL, Unit Nutr Environm & Canc, Canc Epidemiol Res Program, Catalan Inst Oncol, Barcelona 08907, Spain

[2] Paris S Univ, INSERM, Ctr Res Epidemiol & Populat Hlth, Inst Gustave Roussy, Villejuif, France

[3] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[4] Civile MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy

[5] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[6] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[7] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[8] HuGeF, Human Genet Fdn, Turin, Italy

[9] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[10] Ciberesp Biodonostia, San Sebastian, Spain

[11] Granada Canc Registry, Andalusian Sch Publ Health, Granada, Spain

[12] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[13] Navarre Publ Hlth Inst, Pamplona, Spain

[14] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[15] MRC, Epidemiol Unit, Inst Metab Sci, Cambridge, England

[16] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[17] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[18] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[19] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, Sch Publ Hlth, Fac Med, London, England

[20] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[21] Hellen Hlth Fdn, Athens, Greece

[22] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[23] German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany

[24] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[25] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[26] Danish Canc Soc, Diet Genes & Environm Unit, Res Ctr, Copenhagen, Denmark

[27] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

[28] Univ Tromso, Inst Community Med, Tromso, Norway

[29] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden

[30] Lund Univ, Dept Surg, Malmo, Sweden

[31] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[32] Umea Univ, Med Biobank, Umea, Sweden

[33] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[34] Umea Univ, Dept Surg & Publ Hlth, Umea, Sweden

[35] Umea Univ, Dept & Clin Med, Umea, Sweden

[36] Int Agcy Res Canc, Nutr Epidemiol Grp, Nutr & Metab Sect, F-69372 Lyon, France

[37] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London SW7 2AZ, England

[38] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

来源：

INTERNATIONAL JOURNAL OF CANCER | 2013年 / 132卷 / 09期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

pancreatic cancer; menstruation; reproduction; hormones; estrogens; women; CYP17A1; ESTROGEN-BIOSYNTHESIS GENES; HORMONE REPLACEMENT THERAPY; GENOME-WIDE ASSOCIATION; FRANCISCO-BAY AREA; UNITED-STATES; PARITY; CARCINOMA; AGE; MORTALITY; MENARCHE;

D O I：

10.1002/ijc.27875

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (<12 vs. 13 years) was moderately associated with an increased risk of pancreatic cancer in the full cohort; however, this result was marginally significant (HR = 1.44; 95% CI = 0.992.10). CYP17A1 rs619824 was associated with HRT use (p value = 0.037) in control women; however, none of the SNPs alone, in combination, or as haplotypes were associated with pancreatic cancer risk. In conclusion, with the possible exception of an early age of menarche, none of the menstrual and reproductive factors, and none of the 12 common genetic variants we evaluated at the CYP17A1 locus makes a substantial contribution to pancreatic cancer susceptibility in the EPIC cohort.

引用

页码：2164 / 2175

页数：12

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