Immunogenetic predictors of a rapid virologic response to antiviral therapy in patients with chronic hepatitis C

被引：0

作者：

Yushchuk, N. D. ^{[1
]}

Znoiko, O. O. ^{[1
]}

Balmasova, I. P. ^{[1
]}

Fedoseyeva, N. V. ^{[1
]}

Shmeleva, E. V. ^{[1
]}

Dudina, K. R. ^{[1
]}

Klimova, E. A. ^{[1
]}

Petrova, T. V.

Trofimov, D. Yu.

Belyi, P. A. ^{[1
]}

Safiullina, N. Kh. ^{[1
]}

Pypkina, E. V. ^{[1
]}

机构：

[1] AI Evdokimov Moscow State Univ Med & Dent, Minist Hlth & Social Dev Russia, Moscow, Russia

来源：

TERAPEVTICHESKII ARKHIV | 2012年 / 84卷 / 11期

关键词：

chronic hepatitis C; hepatitis C virus; IL28B gene polymorphism; rapid virologic response; natural killer cells; regulatory T cells; PEGYLATED INTERFERON-ALPHA; REGULATORY T-CELLS; GENETIC-VARIATION; VIRUS; IL28B; IFN;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim. To determine the correlation between interleukin 288 (IL28B) gene polymorphism in patients with chronic hepatitis C (CHC), the presence or absence a rapid virologic response to antiviral therapy, and a number of immunological characteristics as a basis for a personalized approach to treating the patients. Subjects and methods. Seventeen CHC patients infected with hepatitis C virus genotype 1b were examined and underwent genetic testing for IL28B gene polymorphism for rs12979860 (CC, CT or TT genotypes) and rs8099917 (TT, TG or GG genotypes) using the modified method of adjacent samples, which revealed single nucleotide substitutions in the genes. Their immunological parameters were identified by a flow cytometry technique by taking into account whether a rapid virologic response had been achieved. Results. The key phenomena of a rapid virologic response in the representatives of different IL28B genotypes are the nonspecific proliferative activity of blood natural killer cells before treatment, as well as the count of regulatory T cells before and 4 weeks after therapy start. Conclusion. To predict the efficiency of antiviral therapy for CHC, it is desirable to supplement genetic studies with immunological data.

引用

页码：11 / +

页数：7