Delayed Graft Function and Long-Term Outcome in Kidney Transplantation

被引：33

作者：

Grosso, G. ^{[2
]}

Corona, D. ^{[1
]}

Mistretta, A. ^{[2
]}

Zerbo, D. ^{[1
]}

Sinagra, N. ^{[1
]}

Giaquinta, A. ^{[1
]}

Cimino, S. ^{[1
]}

Ekser, B. ^{[1
,3
]}

Giuffrida, G. ^{[1
]}

Leonardi, A. ^{[1
]}

Gula, R. ^{[1
]}

Veroux, P. ^{[1
]}

Veroux, M. ^{[1
]}

机构：

[1] Univ Hosp Catania, Vasc Surg & Organ Transplant Unit, Dept Surg Transplantat & Adv Technol, I-95128 Catania, Italy

[2] Univ Hosp Catania, Dept GF Ingrassia, Sect Hyg & Publ Hlth, I-95128 Catania, Italy

[3] Univ Pittsburgh, Med Ctr, Thomas E Starzl Transplantat Inst, Pittsburgh, PA USA

来源：

TRANSPLANTATION PROCEEDINGS | 2012年 / 44卷 / 07期

关键词：

CADAVER RENAL-TRANSPLANTATION; RABBIT ANTITHYMOCYTE GLOBULIN; ACUTE REJECTION; RISK-FACTORS; MULTIVARIATE-ANALYSIS; ALLOGRAFT SURVIVAL; INJURY; IMPACT; ISCHEMIA; HEMODIALYSIS;

D O I：

10.1016/j.transproceed.2012.06.044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. There are still many controversies about the impact of delayed graft function (DGF) on kidney transplantation outcome. The aims of this study were to define factors associated with DGF and to ascertain the relative impact of DGF on kidney transplantation outcome, both in the early postoperative period and in long-term follow-up. Patients and Methods. Four hundred kidney transplant recipients were reviewed to assess the clinical impact of DGF on long-term outcome. Results. The overall prevalence of DGF was 24.3%. DGF was significantly associated with increasing recipient and donor age, duration of dialysis, and cold ischemia time. Patients with DGF displayed a significantly worse graft (P = .005) and patient (P < .001) survival compared with recipients with immediate function. Conclusion. DGF is a frequent complication of renal transplantation and may be associated with a reduced graft and even patient survival. Strategies to prevent graft injury and, more specifically, DGF may be an important clue to provide a better long-term outcome in kidney transplantation.

引用

页码：1879 / 1883

页数：5

共 43 条

[1] POSTISCHEMIC INJURY, DELAYED FUNCTION AND NA+/K+-ATPASE DISTRIBUTION IN THE TRANSPLANTED KIDNEY [J].