Poly(vinyl alcohol)-based membranes for metoprolol transdermal delivery

被引：4

作者：

Algieri, C. ^{[1
]}

Epifanio, A. ^{[1
]}

Garofalo, A. ^{[1
]}

Aljlil, S. A. ^{[2
]}

Donato, L. ^{[1
]}

机构：

[1] Univ Calabria, Natl Res Council Inst Membrane Technol ITM CNR, Cubo 17C,Via Pietro BUCCI, I-87036 Arcavacata Di Rende, CS, Italy

[2] King Abdulaziz City Sci & Technol KACST, Riyadh, Saudi Arabia

来源：

MATERIALS TECHNOLOGY | 2021年 / 36卷 / 07期

关键词：

Metoprolol; transdermal membrane; linear release; RELEASE; FILMS;

D O I：

10.1080/10667857.2020.1769259

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In this work controlled release devices for transdermal administration of metoprolol were developed. Poly(vinyl alcohol) and poly(vinyl pyrrolidone) were used for producing membranes by solvent-casting technique. The release kinetic of the drug from the membranes was evaluated byex-vivoexperimental studies. All the prepared membranes exhibited a linear release profile in the investigated time. The enhancer Tween 80 was added into the polymeric matrices for improving their performance. Different mathematical models were used for fitting the experimental release data. The model that well described the release mechanism was the zero order, indicating a constant drug release in the time.

引用

页码：430 / 439

页数：10

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