Genetic variations in the Hippo signaling pathway and breast cancer risk in African American women in the AMBER Consortium

被引：21

作者：

Zhang, Jianmin ^{[1
]}

Yao, Song ^{[2
]}

Hu, Qiang ^{[3
]}

Zhu, Qianqian ^{[3
]}

Liu, Song ^{[3
]}

Lunetta, Kathryn L. ^{[4
]}

Haddad, Stephen A. ^{[5
]}

Yang, Nuo ^{[1
]}

Shen, He ^{[1
]}

Hong, Chi-Chen ^{[2
]}

Sucheston-Campbell, Lara ^{[2
]}

Ruiz-Narvaez, Edward A. ^{[5
]}

Bensen, Jeannette T. ^{[6
]}

Troester, Melissa A. ^{[6
]}

Bandera, Elisa V. ^{[7
]}

Rosenberg, Lynn ^{[4
]}

Haiman, Christopher A. ^{[8
]}

Olshan, Andrew F. ^{[6
]}

Palmer, Julie R. ^{[5
]}

Ambrosone, Christine B. ^{[2
]}

机构：

[1] Roswell Pk Canc Inst, Dept Canc Genet, Elm & Carlton St, Buffalo, NY 14263 USA

[2] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Elm & Carlton St, Buffalo, NY 14263 USA

[3] Roswell Pk Canc Inst, Dept Biostat & Bioinformat, Elm & Carlton St, Buffalo, NY 14263 USA

[4] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

[5] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA

[6] Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA

[7] State Univ New Jersey, Rutgers Canc Inst New Jersey, Canc Prevent & Control Program, New Brunswick, NJ 08901 USA

[8] Univ Southern Calif, Norris Comprehens Canc Ctr, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA

来源：

CARCINOGENESIS | 2016年 / 37卷 / 10期

关键词：

E-CADHERIN EXPRESSION; YAP PATHWAY; TAZ; ASSOCIATION; METASTASIS; TUMORIGENESIS; PHOSPHATASE; DISPARITIES; RECEPTOR; COMPLEX;

D O I：

10.1093/carcin/bgw077

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiological studies indicate that African-American (AA) women are more likely to be diagnosed with more aggressive breast cancer. In this first large study of common genetic variants in the Hippo signaling pathway with breast cancer risk in AA women, we found that this pathway was specifically associated with ER-negative breast cancer risk.The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Dysfunction of the Hippo pathway components has been linked with breast cancer stem cell regulation, as well as breast tumor progression and metastasis. TAZ, a key component of the Hippo pathway, is highly expressed in triple negative breast cancer; however, the associations of genetic variations in this important pathway with breast cancer risk remain largely unexplored. Here, we analyzed 8309 germline variants in 15 genes from the Hippo pathway with a total of 3663 cases and 4687 controls from the African American Breast Cancer Epidemiology and Risk Consortium. Odds ratios (ORs) were estimated using logistic regression for overall breast cancer, by estrogen receptor (ER) status (1983 ER positive and 1098 ER negative), and for case-only analyses by ER status. The Hippo signaling pathway was significantly associated with ER-negative breast cancer (pathway level P = 0.02). Gene-based analyses revealed that CDH1 was responsible for the pathway association (P < 0.01), with rs4783673 in CDH1 statistically significant after gene-level adjustment for multiple comparisons (P = 9.2x10(-5), corrected P = 0.02). rs142697907 in PTPN14 was associated with ER-positive breast cancer and rs2456773 in CDK1 with ER-negativity in case-only analysis after gene-level correction for multiple comparisons (corrected P < 0.05). In conclusion, common genetic variations in the Hippo signaling pathway may contribute to both ER-negative and ER+ breast cancer risk in AA women.

引用

页码：951 / 956

页数：6

共 56 条

[1]

Acs G, 2001, AM J CLIN PATHOL, V115, P85

[2] An integrated map of genetic variation from 1,092 human genomes [J].

Altshuler, David M. ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Donnelly, Peter ;

Eichler, Evan E. ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Green, Eric D. ;

Hurles, Matthew E. ;

Knoppers, Bartha M. ;

Korbel, Jan O. ;

Lander, Eric S. ;

Lee, Charles ;

Lehrach, Hans ;

Mardis, Elaine R. ;

Marth, Gabor T. ;

McVean, Gil A. ;

Nickerson, Deborah A. ;

Schmidt, Jeanette P. ;

Sherry, Stephen T. ;

Wang, Jun ;

Wilson, Richard K. ;

Gibbs, Richard A. ;

Dinh, Huyen ;

Kovar, Christie ;

Lee, Sandra ;

Lewis, Lora ;

Muzny, Donna ;

Reid, Jeff ;

Wang, Min ;

Wang, Jun ;

Fang, Xiaodong ;

Guo, Xiaosen ;

Jian, Min ;

Jiang, Hui ;

Jin, Xin ;

Li, Guoqing ;

Li, Jingxiang ;

Li, Yingrui ;

Li, Zhuo ;

Liu, Xiao ;

Lu, Yao ;

Ma, Xuedi ;

Su, Zhe ;

Tai, Shuaishuai ;

Tang, Meifang .

NATURE, 2012, 491 (7422) :56-65

[3] Conducting Molecular Epidemiological Research in the Age of HIPAA: A Multi-Institutional Case-Control Study of Breast Cancer in African-American and European-American Women [J].

Ambrosone, Christine B. ;

Ciupak, Gregory L. ;

Bandera, Elisa V. ;

Jandorf, Lina ;

Bovbjerg, Dana H. ;

Zirpoli, Gary ;

Pawlish, Karen ;

Godbold, James ;

Furberg, Helena ;

Fatone, Anne ;

Valdimarsdottir, Heiddis ;

Yao, Song ;

Li, Yulin ;

Hwang, Helena ;

Davis, Warren ;

Roberts, Michelle ;

Sucheston, Lara ;

Demissie, Kitaw ;

Amend, Kandace L. ;

Tartter, Paul ;

Reilly, James ;

Pace, Benjamin W. ;

Rohan, Thomas ;

Sparano, Joseph ;

Raptis, George ;

Castaldi, Maria ;

Estabrook, Alison ;

Feldman, Sheldon ;

Weltz, Christina ;

Kemeny, Margaret .

JOURNAL OF ONCOLOGY, 2009, 2009

[4] Breast cancer in African-American women: differences in tumor biology from European-American women [J].

Amend, Kandace ;

Hicks, David ;

Ambrosone, Christine B. .

CANCER RESEARCH, 2006, 66 (17) :8327-8330

[5] A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors [J].

Aragona, Mariaceleste ;

Panciera, Tito ;

Manfrin, Andrea ;

Giulitti, Stefano ;

Michielin, Federica ;

Elvassore, Nicola ;

Dupont, Sirio ;

Piccolo, Stefano .

CELL, 2013, 154 (05) :1047-1059

[6] Rethinking sources of representative controls for the conduct of case-control studies in minority populations [J].

Bandera, Elisa V. ;

Chandran, Urmila ;

Zirpoli, Gary ;

McCann, Susan E. ;

Ciupak, Gregory ;

Ambrosone, Christine B. .

BMC MEDICAL RESEARCH METHODOLOGY, 2013, 13

[7] TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells [J].

Bartucci, M. ;

Dattilo, R. ;

Moriconi, C. ;

Pagliuca, A. ;

Mottolese, M. ;

Federici, G. ;

Di Benedetto, A. ;

Todaro, M. ;

Stassi, G. ;

Sperati, F. ;

Amabile, M. I. ;

Pilozzi, E. ;

Patrizii, M. ;

Biffoni, M. ;

Maugeri-Sacca, M. ;

Piccolo, S. ;

De Maria, R. .

ONCOGENE, 2015, 34 (06) :681-690

[8] The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking [J].

Belle, Leila ;

Ali, Naveid ;

Lonic, Ana ;

Li, Xiaochun ;

Paltridge, James L. ;

Roslan, Suraya ;

Herrmann, David ;

Conway, James R. W. ;

Gehling, Freya K. ;

Bert, Andrew G. ;

Crocker, Lesley A. ;

Tsykin, Anna ;

Farshid, Gelareh ;

Goodall, Gregory J. ;

Timpson, Paul ;

Daly, Roger J. ;

Khew-Goodall, Yeesim .

SCIENCE SIGNALING, 2015, 8 (364)

[9] Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma [J].

Bonilla, Ximena ;

Parmentier, Laurent ;

King, Bryan ;

Bezrukov, Fedor ;

Kaya, Gurkan ;

Zoete, Vincent ;

Seplyarskiy, Vladimir B. ;

Sharpe, Hayley J. ;

McKee, Thomas ;

Letourneau, Audrey ;

Ribaux, Pascale G. ;

Popadin, Konstantin ;

Basset-Seguin, Nicole ;

Ben Chaabene, Rouaa ;

Santoni, Federico A. ;

Andrianova, Maria A. ;

Guipponi, Michel ;

Garieri, Marco ;

Verdan, Carole ;

Grosdemange, Kerstin ;

Sumara, Olga ;

Eilers, Martin ;

Aifantis, Iannis ;

Michielin, Olivier ;

de Sauvage, Frederic J. ;

Antonarakis, Stylianos E. ;

Nikolaev, Sergey I. .

NATURE GENETICS, 2016, 48 (04) :398-+

[10] An evolutionary shift in the regulation of the Hippo pathway between mice and flies [J].

Bossuyt, W. ;

Chen, C-L ;

Chen, Q. ;

Sudol, M. ;

McNeill, H. ;

Pan, D. ;

Kopp, A. ;

Halder, G. .

ONCOGENE, 2014, 33 (10) :1218-1228

← 1 2 3 4 5 6 →