Dynamics of Cell Generation and Turnover in the Human Heart

被引：831

作者：

Bergmann, Olaf ^{[1
]}

Zdunek, Sofia ^{[1
]}

Felker, Anastasia ^{[1
]}

Salehpour, Mehran ^{[2
]}

Alkass, Kanar ^{[1
,3
]}

Bernard, Samuel ^{[4
]}

Sjostrom, Staffan L. ^{[1
]}

Szewczykowska, Mirosawa ^{[5
]}

Jackowska, Teresa ^{[5
,6
]}

dos Remedios, Cris ^{[7
]}

Malm, Torsten ^{[8
]}

Andrae, Michaela ^{[9
,10
]}

Jashari, Ramadan ^{[11
]}

Nyengaard, Jens R. ^{[12
]}

Possnert, Goran ^{[2
]}

Jovinge, Stefan ^{[13
,14
,15
]}

Druid, Henrik ^{[3
]}

Frisen, Jonas ^{[1
]}

机构：

[1] Karolinska Inst, Dept Cellular & Mol Biol, S-17177 Stockholm, Sweden

[2] Uppsala Univ, Dept Phys & Astron, Div Ion Phys, S-75120 Uppsala, Sweden

[3] Karolinska Inst, Dept Forens Med, S-17177 Stockholm, Sweden

[4] Univ Lyon, Inst Camille Jordan, Dept Math, F-69622 Villeurbanne, France

[5] Bielanski Hosp, Dept Pediat, PL-01809 Warsaw, Poland

[6] Med Ctr Postgrad Educ, Dept Pediat, PL-01813 Warsaw, Poland

[7] Univ Sydney, Bosch Inst, Discipline Anat, Sydney, NSW 2006, Australia

[8] Skane Univ Hosp, Dept Paediat Cardiac Surg, S-22185 Lund, Sweden

[9] Med Univ Graz, Klinikum Klagenfurt, A-9020 Graz, Austria

[10] Med Univ Graz, Sect Surg Res, Dept Cardiothorac & Vasc Surg, A-9020 Graz, Austria

[11] European Homograft Bank, B-1120 Brussels, Belgium

[12] Aarhus Univ, Ctr Stochast Geometry & Adv Bioimaging, Stereol & Elect Microscopy Lab, DK-8000 Aarhus, Denmark

[13] Spectrum Hlth Frederik Meijer Heart & Vasc Inst, Grand Rapids, MI 49503 USA

[14] Van Andel Inst, Grand Rapids, MI 49503 USA

[15] Lund Univ, Stem Cell Ctr, S-22184 Lund, Sweden

来源：

CELL | 2015年 / 161卷 / 07期

基金：

瑞典研究理事会;

关键词：

CARDIOMYOCYTE DNA-SYNTHESIS; CARDIAC STEM-CELLS; MYOCARDIAL-INFARCTION; IN-VIVO; ADULT HEART; REGENERATION; NUCLEI; NUMBER; PROLIFERATION; MYOCYTES;

D O I：

10.1016/j.cell.2015.05.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived C-14 revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart.

引用

页码：1566 / 1575

页数：10

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