Nitric oxide and cell death

被引：363

作者：

Murphy, MP ^{[1
]}

机构：

[1] Univ Otago, Dept Biochem, Dunedin, New Zealand

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 1999年 / 1411卷 / 2-3期

关键词：

nitric oxide; cell death; apoptosis; necrosis; neurodegeneration; ischemia-reperfusion injury; glutamate toxicity;

D O I：

10.1016/S0005-2728(99)00029-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) has several essential roles in mammals, but unregulated NO production can cause cell death through oxidative stress, disrupted energy metabolism DNA damage, activation of poly(ADP-ribose) polymerase, or dysregulation of cytosolic calcium. Such disturbances can lead to either apoptotic or necrotic cell death, depending on the severity and context of the damage. Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：401 / 414

页数：14

共 158 条

[1] GLUTAMATE-INDUCED NEURONAL DEATH - A SUCCESSION OF NECROSIS OR APOPTOSIS DEPENDING ON MITOCHONDRIAL-FUNCTION [J].