Nitric oxide and cell death

被引：359
|
作者：
Murphy, MP [1 ]
机构：
[1] Univ Otago, Dept Biochem, Dunedin, New Zealand
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 1999年 / 1411卷 / 2-3期
关键词：
nitric oxide; cell death; apoptosis; necrosis; neurodegeneration; ischemia-reperfusion injury; glutamate toxicity;
D O I：
10.1016/S0005-2728(99)00029-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide (NO) has several essential roles in mammals, but unregulated NO production can cause cell death through oxidative stress, disrupted energy metabolism DNA damage, activation of poly(ADP-ribose) polymerase, or dysregulation of cytosolic calcium. Such disturbances can lead to either apoptotic or necrotic cell death, depending on the severity and context of the damage. Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：401 / 414
页数：14
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