Tuberculin reactivity in first-year schoolchildren in Madagascar

被引:6
作者
Raharimanga, Vaomalala [1 ]
Ratovoson, Rila [1 ]
Ratsitorahina, Maherisoa [1 ]
Ramarokoto, Herimanana [2 ]
Rasolofo, Voahangy [1 ]
Talarmin, Antoine [1 ]
Richard, Vincent [1 ]
机构
[1] Inst Pasteur Madagascar, Antananarivo, Madagascar
[2] Minist Hlth, Natl TB Programme, Antananarivo, Madagascar
关键词
tuberculosis; Bacille Calmette-Guerin vaccine; tuberculin skin test; Madagascar; Tuberculose (TB); vaccin BCG; test cutane tuberculinique (TCT); Tuberculosis (TB); vacuna BCG; prueba cutanea de tuberculina; SKIN-TEST; BCG VACCINATION; SCHOOL-CHILDREN; INFECTION; EPIDEMIOLOGY; CONTACT; BIRTH; TESTS; RISK;
D O I
10.1111/j.1365-3156.2012.03013.x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective The tuberculin skin test (TST) is an important tool in the diagnosis of tuberculosis infection in children. However, the interpretation of TST may be complicated by prior Bacillus Calmette-Guerin (BCG) vaccination. We evaluated the effect of vaccination with BCG on TST reactivity in first-year pupils attending state schools in Antananarivo. Methods STs were performed on 376 first-year schoolchildren, aged 6 and 7, attending two state primary schools. The relationships between epidemiological information, BCG status (vaccination, BCG scars) and TST reactivity were assessed to compare TST sensitivity between children with and without BCG vaccination and between those with and without a BCG scar. Result The prevalence of positive TST results of =5, =10 and = 15 mm was 20.2% (76/376), 18.3% (69/376) and 11.4% (43/376), respectively. BCG vaccination was not associated with TST reactivity, whatever the threshold used: =5 mm (odds ratio (OR, 1.2; 95% confidence interval (CI), 0.72.0); =10 mm (OR, 0.9; 95% CI, 0.61.7); =15 mm (OR, 0.6; 95% CI, 0.31.2). Conclusion These results suggest that in Madagascar, a positive TST result indicates TB infection (active or latent) rather than past BCG vaccination. Therefore, high BCG vaccination coverage does not appear to impair the usefulness of the TST as a tool for diagnosing tuberculosis.
引用
收藏
页码:871 / 876
页数:6
相关论文
共 27 条
  • [21] Spatial clustering of pulmonary tuberculosis and impact of the care factors in Antananarivo City
    Randremanana, Rindra Vatosoa
    Sabatier, Philippe
    Rakotomanana, Fanjasoa
    Randriamanantena, Arthur
    Richard, Vincent
    [J]. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2009, 14 (04) : 429 - 437
  • [22] Saito M, 2004, INT J TUBERC LUNG D, V8, P842
  • [23] Salehzadeh F., 2009, International Journal of Tropical Medicine, V4, P37
  • [24] Tuberculin test measurement - Variability due to the time of reading
    Singh, D
    Sutton, C
    Woodcock, A
    [J]. CHEST, 2002, 122 (04) : 1299 - 1301
  • [25] Interpretation of the tuberculin skin test in bacille Calmette-Guerin vaccinated and nonvaccinated school children
    Sleiman, Rola
    Al-Tannir, Mohamad
    Dakdouki, Ghenwa
    Ziade, Fouad
    Abou Assi, Nahla
    Rajab, Mariam
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2007, 26 (02) : 134 - 138
  • [26] Suciliene E, 1999, INT J TUBERC LUNG D, V3, P956
  • [27] Yu MC, 1999, J FORMOS MED ASSOC, V98, P496