Basiliximab in the treatment of acute steroid-resistant rejection after liver transplantation

被引：2

作者：

Alvarez Castro, Ana M. ^{[1
]}

Seijo Rios, Susana ^{[1
]}

Molina Perez, Esther ^{[1
]}

Castroagudin, Javier F. ^{[1
]}

Varo Perez, Evaristo ^{[1
]}

机构：

[1] Hosp Clin Univ Santiago, Unidad Trasplantes Abdominales, Santiago De Compostela, Spain

来源：

GASTROENTEROLOGIA Y HEPATOLOGIA | 2012年 / 35卷 / 09期

关键词：

Liver transplantation; Acute steroid-resistant rejection; Basiliximab; RISK-FACTORS;

D O I：

10.1016/j.gastrohep.2012.03.016

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We present the case of a liver transplant recipient with alcoholic liver cirrhosis and early-stage hepatocellular carcinoma who developed biopsy-proven acute steroid-resistant rejection 3 months after liver transplantation. After the failure of immunosuppressive therapy with intravenous boluses of 6-methyl-prednisolone and switching of the immunosuppressive regimen to tacrolimus plus mycophenolate mofetil, two doses of intravenous basiliximab were administered four days apart. Clinical, analytical, and biopsy-proven histological response was complete. No basiliximab-related adverse events were detected. Basiliximab may represent an alternative in liver transplantation immunosuppression to treat acute steroid-resistant rejection, without increasing the incidence of infections, neoplasms, or other adverse events, as shown by this case. (C) 2012 Elsevier Espana, S.L. and AEEH y AEG. All rights reserved.

引用

页码：649 / 651

页数：3

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