Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

被引:75
作者
Dumez, Jean-Nicolas [1 ]
Milani, Jonas [2 ]
Vuichoud, Basile [2 ]
Bornet, Aurelien [2 ]
Lalande-Martin, Julie [3 ]
Tea, Illa [3 ,4 ]
Yon, Maxime [3 ,5 ]
Maucourt, Mickael [6 ,7 ]
Deborde, Catherine [6 ,8 ]
Moing, Annick [6 ,8 ]
Frydman, Lucio [5 ]
Bodenhausen, Geoffrey [2 ,9 ,10 ,11 ]
Jannin, Sami [2 ]
Giraudeau, Patrick [3 ,12 ]
机构
[1] CNRS, Inst Chim Subst Nat, UPR 2301, F-91190 Gif Sur Yvette, France
[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
[3] Univ Nantes, CNRS, CEISAM UMR 6230, F-44322 Nantes 03, France
[4] Australian Natl Univ, Canc Metab & Genet Grp, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
[5] Weizmann Inst Sci, Dept Chem Phys, IL-76100 Rehovot, Israel
[6] Ctr INRA Bordeaux, Ctr Genom Fonct Bordeaux, Plateforme Metabolome Bordeaux MetaboHUB, IBVM, F-33140 Villenave Dornon, France
[7] Univ Bordeaux, UMR Biol Fruit & Pathol 1332, Ctr INRA Bordeaux, F-33140 Villenave Dornon, France
[8] INRA, Ctr INRA Bordeaux, UMR Biol Fruit & Pathol 1332, F-33140 Villenave Dornon, France
[9] Paris Sci Lettres PSL Res Univ, Ecole Normale Super, Dept Chim, F-75005 Paris, France
[10] Sorbonne Univ, Univ Paris 06, Lab Biomol LBM, F-75005 Paris, France
[11] CNRS, Lab Biomol LBM, Unite Mixte Rech UMR 7203, F-75005 Paris, France
[12] Inst Univ France, F-75005 Paris, France
基金
瑞士国家科学基金会; 欧洲研究理事会;
关键词
DYNAMIC NUCLEAR-POLARIZATION; SPECTRA;
D O I
10.1039/c5an01203a
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Natural abundance C-13 NMR spectra of biological extracts are recorded in a single scan provided that the samples are hyperpolarized by dissolution dynamic nuclear polarization combined with cross polarization. Heteronuclear 2D correlation spectra of hyperpolarized breast cancer cell extracts can also be obtained in a single scan. Hyperpolarized NMR of extracts opens many perspectives for metabolomics.
引用
收藏
页码:5860 / 5863
页数:4
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