Design, Synthesis & Biological Evaluation of Some Novel Quinazolinone Scaffolds

被引：12

作者：

Modh, Rahul P. ^{[1
]}

Patel, Amit C. ^{[2
]}

Chikhalia, Kishor H. ^{[1
]}

机构：

[1] Gujarat Univ, Sch Sci, Dept Chem, Ahmadabad 380009, Gujarat, India

[2] Veer Narmad S Gujarat Univ, Dept Chem, Surat, Gujarat, India

来源：

MEDICINAL CHEMISTRY | 2012年 / 8卷 / 02期

关键词：

Antibacterial study; antifungal study; dimethoxyphenyl ethanamine; quinazolin-4(3H)-one; semicarbazide; styryl; thiophen-2-ethylamine; CYTOTOXIC ACTIVITY; SCHIFF-BASES; DERIVATIVES; ANTIBACTERIAL; INHIBITOR; ANALOGS; ANTIBIOTICS; SERIES; AGENTS;

D O I：

10.2174/157340612800493610

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In an effort to discover new candidates with improved antimicrobial activities, we synthesized and studied in-vitro antimicrobial activities of various series of 3-((thiophen-2-yl)-ethyl)-2-(styryl)-quinazolin-4(3H)-one (3a-3g) and N-1-(substituted aryl)-N3-[3-((3,4-dimethoxy phenyl-2-yl)-ethyl)-4(3H)-quinazolone-2-yl]-acetonyl semicarbazides (7a-7j) with an intent to overcome multiple drug resistance to the pathogenic strains and to retain psychological action to develop novel class of antibacterial agents. The structure of newly synthesized scaffolds has been affirmed on the basis of FTIR, H-1 NMR, C-13 NMR, mass and elemental analysis. All the final scaffolds have been subjected to in vitro antimicrobial screening against two Gram (+Ve) bacteria (S. aureus, B. subtilis), two Gram (-Ve) bacteria (E. coli, S. typhi) and two fungal strains (C. albicans, A. niger) using the broth micro-dilution method.

引用

页码：182 / 192

页数：11

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