A Study on Injectable Bone Cement

Calcium phosphate materials are used as cements, composites and coatings in many medical and dental applications due to their similarity to bone both in composition and in osteoconductive and osteoactive properties. Injectable cement is used in hard tissue repair as an adjunct to internal fixation of fractures. In this study, we experimented with the production and characterization of Ca-P and silk based injectable calcium phosphate cement. HA, TCP, Na2HPO4 and polyamide solution were used to produce injectable bone cement. Mixing and solidification time was documented. The injectable cement material was characterized using XRD, SEM and FTIR. Characterization of samples indicated that a CHA-polymer based injectable cement with a setting time of four minutes and solidification time of ten minutes was obtained. Further studies on cytotoxicity and biocompatibility as well as improvement on solidification time will be conducted.