Tropical Plant Extracts as Potential Antihyperglycemic Agents

被引：36

作者：

Manaharan, Thamilvaani ^{[1
]}

Palanisamy, Uma Devi ^{[2
]}

Ming, Cheng Hwee ^{[1
]}

机构：

[1] Univ Malaya, Fac Med, Dept Physiol, Kuala Lumpur 50603, Malaysia

[2] Monash Univ, Sch Med & Hlth Sci, Bandar Sunway 46150, Selangor, Malaysia

来源：

MOLECULES | 2012年 / 17卷 / 05期

关键词：

type 2 diabetes mellitus; alpha-glucosidase; alpha-amylase; antioxidant; total phenolic content; ALPHA-AMYLASE ACTIVITY; SYZYGIUM-CUMINI; MALAYSIAN PLANTS; MEDICINAL-PLANTS; ANTIOXIDANT; CAPACITY; SEEDS; ASSAY;

D O I：

10.3390/molecules17055915

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Preliminary investigations on 14 plant extracts (obtained by ethanolic and aqueous extraction) identified those having high antioxidant and a significant total phenolic content. Antihyperglycemic, alpha-amylase and alpha-glucosidase inhibition activities were also observed. A correlation between the antihyperglycemic activity, total phenolic content and antioxidant (DPPH scavenging) activity was established. To further substantiate these findings, the possibility of tannins binding non-specifically to enzymes and thus contributing to the antihyperglycemic activity was also investigated. Our study clearly indicated that the antihyperglycemic activity observed in the plant extracts was indeed not due to non-specific tannin absorption.

引用

页码：5915 / 5923

页数：9

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