Molecular Crosstalk between the Immunological Mechanism of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Oral Cancer

被引:1
作者
Renu, Kaviyarasi [1 ]
Vinayagam, Sathishkumar [2 ]
Veeraraghavan, Vishnu Priya [1 ]
Mukherjee, Anirban Goutam [3 ]
Wanjari, Uddesh Ramesh [3 ]
Prabakaran, D. S. [4 ,5 ]
Ganesan, Raja [6 ]
Dey, Abhijit [7 ]
Vellingiri, Balachandar [8 ]
Kandasamy, Sabariswaran [9 ]
Ramanathan, Gnanasambandan [3 ]
Doss, George Priya C. [10 ]
George, Alex [11 ]
Gopalakrishnan, Abilash Valsala [3 ]
机构
[1] Saveetha Univ, Saveetha Dent Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Mol Med & Diagnost COMManD,Dept Biochem, Chennai 600077, Tamil Nadu, India
[2] Periyar Univ, Ctr Postgrad & Res Studies, Dept Biotechnol, Dharmapuri 635205, Tamil Nadu, India
[3] Vellore Inst Technol VIT, Sch Biosci & Technol, Dept Biomed Sci, Vellore 632014, Tamil Nadu, India
[4] Chungbuk Natl Univ, Coll Med, Dept Radiat Oncol, Chungdae Ro 1, Cheongju 28644, South Korea
[5] Ayya Nadar Janaki Ammal Coll Autonomous, Dept Biotechnol, Srivilliputhur Main Rd, Sivakasi 626124, Tamil Nadu, India
[6] Hallym Univ, Inst Liver & Digest Dis, Chunchon 24252, South Korea
[7] Presidency Univ, Dept Life Sci, Kolkata 700073, W Bengal, India
[8] Bharathiar Univ, Dept Human Genet & Mol Biol, Human Mol Cytogenet & Stem Cell Lab, Coimbatore 641046, Tamil Nadu, India
[9] Jiangsu Univ, Inst Energy Res, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China
[10] Vellore Inst Technol VIT, Sch BioSci & Technol, Dept Integrat Biol, Vellore 632014, Tamil Nadu, India
[11] Jubilee Mission Med Coll & Res Inst, Jubilee Ctr Med Res, Trichur 680005, Kerala, India
关键词
oral cancer; immunological aspects; microenvironment; epithelial-to-mesenchymal transition; signaling events; SQUAMOUS-CELL CARCINOMA; PROGNOSTIC VALUE; E-CADHERIN; OVER-EXPRESSION; NECK-CANCER; HEAD; EMT; MIGRATION; INVASION; METASTASIS;
D O I
10.3390/vaccines10091490
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Oral cancer is a significant non-communicable disease affecting both emergent nations and developed countries. Squamous cell carcinoma of the head and neck represent the eight major familiar cancer types worldwide, accounting for more than 350,000 established cases every year. Oral cancer is one of the most exigent tumors to control and treat. The survival rate of oral cancer is poor due to local invasion along with recurrent lymph node metastasis. The tumor microenvironment contains a different population of cells, such as fibroblasts associated with cancer, immune-infiltrating cells, and other extracellular matrix non-components. Metastasis in a primary site is mainly due to multifaceted progression known as epithelial-to-mesenchymal transition (EMT). For the period of EMT, epithelial cells acquire mesenchymal cell functional and structural characteristics, which lead to cell migration enhancement and promotion of the dissemination of tumor cells. The present review links the tumor microenvironment and the role of EMT in inflammation, transcriptional factors, receptor involvement, microRNA, and other signaling events. It would, in turn, help to better understand the mechanism behind the tumor microenvironment and EMT during oral cancer.
引用
收藏
页数:15
相关论文
共 95 条
  • [41] CCL2 promotes cell migration by inducing epithelial-mesenchymal transition in oral squamous cell carcinoma
    Ling, Zihang
    Yang, Xi
    Chen, Xiaobin
    Xia, Juan
    Cheng, Bin
    Tao, Xiaoan
    [J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2019, 48 (06) : 477 - 482
  • [42] Liu H., 2022, DIS MARKERS, V2022
  • [43] Lopez-Labady J., 2021, FRONT ORAL HLTH, V2
  • [44] Molecular markers of head and neck squamous cell carcinoma: Promising signs in need of prospective evaluation
    Lothaire, P
    de Azambuja, E
    Dequanter, D
    Lalami, Y
    Sotiriou, C
    Andry, G
    Castro, G
    Awada, A
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2006, 28 (03): : 256 - 269
  • [45] Marimuthu Madhulaxmi, 2018, Indian J Dent Res, V29, P291, DOI 10.4103/ijdr.IJDR_375_17
  • [46] FGF-2 and FGFR-1 might be independent prognostic factors in oral tongue squamous cell carcinoma
    Mariz, Bruno A. L. A.
    Soares, Ciro D.
    de Carvalho, Maria G. F.
    Jorge-Junior, Jacks
    [J]. HISTOPATHOLOGY, 2019, 74 (02) : 311 - 320
  • [47] Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge
    Marzano Rodrigues Petruzzi, Maria Noel
    Cherubini, Karen
    Salum, Fernanda Goncalves
    Zancanaro de Figueiredo, Maria Antonia
    [J]. DIAGNOSTIC PATHOLOGY, 2017, 12
  • [48] Matsuhira Akiko, 2015, Bull Tokyo Dent Coll, V56, P223, DOI 10.2209/tdcpublication.56.223
  • [49] De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones
    McCauley, Heather A.
    Chevrier, Veronique
    Birnbaum, Daniel
    Guasch, Geraldine
    [J]. ELIFE, 2017, 6
  • [50] Downregulation of TGF-beta receptor types II and III in oral squamous cell carcinoma and oral carcinoma-associated fibroblasts
    Meng, Wenxia
    Xia, Qingjie
    Wu, Lanyan
    Chen, Sixiu
    He, Xin
    Zhang, Lin
    Gao, Qinghong
    Zhou, Hongmei
    [J]. BMC CANCER, 2011, 11