Factors linked to foveoschisis in high myopia

Purpose. - To investigate the factors linked to foveoschisis in high myopia. Methods. -Retrospective study of 113 patients (200 eyes) with high myopia was conducted between January 2010 and June 2012. Subjects underwent a complete ophthalmic examination, spectral domain optical coherence tomography (OCT TOPCON 2000) and ocular echography. Results. - Of the 200 eyes, 22 (11%) had foveoschisis on OCT examination. On the basis of univariate analysis, five variables were associated with the pathologic changes, including spherical equivalent over 10 diopters (P = 0.044), axial length over 30 mm (P = 0.0028), macular chorioretinal atrophy (P = 0.0009), posterior staphyloma (P = 0.0007) and vitreoretinal interface factors (P = 0.0002). In the multivariate analysis, three factors were independently associated with foveoschisis in high myopia: axial length (adjusted OR, 16.7; IC 95% 1.4-219.7, P = 0.036), macular chorioretinal atrophy (adjusted OR, 13.2; IC 95%, 1.3-133.1, P = 0.044), and vitreoretinal interface factors (adjusted OR, 36.1; IC 95%, 3.5-376.9, P = 0.002). Conclusions. - In our study, axial length, macular chorioretinal atrophy, and vitreoretinal interface factors were independently associated foveoschisis in highly myopic eyes. (c) 2014 Elsevier Masson SAS. All rights reserved.