Deletion of the activating NKG2C receptor and a functional polymorphism in its ligand HLA-E in psoriasis susceptibility
被引:33
作者:
Zeng, Xue
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机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
China Acad Chinese Med Sci, Guanganmen Hosp, Dept Dermatol, Beijing, Peoples R ChinaUniv Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Zeng, Xue
[1
,2
]
Chen, Haoyan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Shanghai Jiao Tong Univ, Dept Gastroenterol, Ren Ji Hosp, Sch Med,Shanghai Inst Digest Dis, Shanghai 200030, Peoples R ChinaUniv Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Chen, Haoyan
[1
,3
]
Gupta, Rashmi
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h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Gupta, Rashmi
[1
]
Paz-Altschul, Oscar
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Paz-Altschul, Oscar
[1
]
Bowcock, Anne M.
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机构:
Univ London Imperial Coll Sci Technol & Med, Canc Genom & Natl Heart & Lung Inst, London, EnglandUniv Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Bowcock, Anne M.
[4
]
Liao, Wilson
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h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Liao, Wilson
[1
]
机构:
[1] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
[2] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Dermatol, Beijing, Peoples R China
[3] Shanghai Jiao Tong Univ, Dept Gastroenterol, Ren Ji Hosp, Sch Med,Shanghai Inst Digest Dis, Shanghai 200030, Peoples R China
[4] Univ London Imperial Coll Sci Technol & Med, Canc Genom & Natl Heart & Lung Inst, London, England
Psoriasis is an inflammatory, immune-mediated disease of the skin. Several studies have suggested that natural killer (NK) cells and their receptors may be important for its pathogenesis. Here, we examined whether deletion of the activating natural killer receptor gene NKG2C, which has a frequency of 20% in the European population, was associated with psoriasis susceptibility. The NKG2C deletion and a functional polymorphism in its ligand HLA-E were genotyped in a Caucasian cohort of 611 psoriasis cases and 493 controls. We found that the NKG2C deletion was significantly increased in cases compared with controls [0.258 vs 0.200, P=0.0012, OR=1.43 (1.15-1.79)]. The low-expressing HLA-E*01:01 allele was associated with psoriasis (P=0.0018), although this association was dependent on HLA-C. Our findings support a potential immunoregulatory role for NK cells in psoriasis and suggest the importance of future studies to investigate the contribution of NK cells and their regulatory receptors to the pathogenesis of psoriasis.
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Univ Sao Paulo, Div Clin Immunol & Allergy, LIM 60, Sch Med, BR-01246903 Sao Paulo, BrazilUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Batista, Mariana D.
;
Ho, Emily L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Ho, Emily L.
;
Kuebler, Peter J.
论文数: 0引用数: 0
h-index: 0
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Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Kuebler, Peter J.
;
Milush, Jeffrey M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Milush, Jeffrey M.
;
Lanier, Lewis L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Canc Res Inst, Dept Microbiol & Immunol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Lanier, Lewis L.
;
Kallas, Esper G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Invest Imunol, Sao Paulo, BrazilUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Kallas, Esper G.
;
York, Vanessa A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
York, Vanessa A.
;
Chang, David
论文数: 0引用数: 0
h-index: 0
机构:
Calif Pacific Med Ctr, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Chang, David
;
Liao, Wilson
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Liao, Wilson
;
Unemori, Patrick
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h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Unemori, Patrick
;
Leslie, Kieron S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Leslie, Kieron S.
;
Maurer, Toby
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Maurer, Toby
;
Nixon, Douglas F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
机构:
Kobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
Fujiwara, Susumu
;
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机构:
Nagai, Hiroshi
;
Oniki, Shuntaro
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
Oniki, Shuntaro
;
Yoshimoto, Takayuki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Intractable Dis Res Ctr, Tokyo, JapanKobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
Yoshimoto, Takayuki
;
Nishigori, Chikako
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
机构:
Technion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Flieman Med Ctr, Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Gilhar, Amos
;
Keren, Aviad
论文数: 0引用数: 0
h-index: 0
机构:
Technion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Flieman Med Ctr, Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Keren, Aviad
;
Shemer, Avner
论文数: 0引用数: 0
h-index: 0
机构:
Technion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Flieman Med Ctr, Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Shemer, Avner
;
d'Ovidio, Roberto
论文数: 0引用数: 0
h-index: 0
机构:
Assoc Italiana Dermatol Ambulatoriali, Bari, ItalyTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
d'Ovidio, Roberto
;
Ullmann, Yehuda
论文数: 0引用数: 0
h-index: 0
机构:
Technion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Flieman Med Ctr, Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Ullmann, Yehuda
;
Paus, Ralf
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ Lubeck, Dept Dermatol, D-23538 Lubeck, Germany
Univ Manchester, Inst Inflammat & Repair, Manchester, Lancs, EnglandTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
机构:
Univ Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, EnglandUniv Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, England
Hodgkinson, AD
;
Millward, BA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, EnglandUniv Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, England
Millward, BA
;
Demaine, AG
论文数: 0引用数: 0
h-index: 0
机构:
Univ Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, EnglandUniv Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, England
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Univ Sao Paulo, Div Clin Immunol & Allergy, LIM 60, Sch Med, BR-01246903 Sao Paulo, BrazilUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Batista, Mariana D.
;
Ho, Emily L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Ho, Emily L.
;
Kuebler, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Kuebler, Peter J.
;
Milush, Jeffrey M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Milush, Jeffrey M.
;
Lanier, Lewis L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Canc Res Inst, Dept Microbiol & Immunol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Lanier, Lewis L.
;
Kallas, Esper G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Invest Imunol, Sao Paulo, BrazilUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Kallas, Esper G.
;
York, Vanessa A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
York, Vanessa A.
;
Chang, David
论文数: 0引用数: 0
h-index: 0
机构:
Calif Pacific Med Ctr, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Chang, David
;
Liao, Wilson
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Liao, Wilson
;
Unemori, Patrick
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Unemori, Patrick
;
Leslie, Kieron S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Leslie, Kieron S.
;
Maurer, Toby
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
Maurer, Toby
;
Nixon, Douglas F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USAUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA USA
机构:
Kobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
Fujiwara, Susumu
;
论文数: 引用数:
h-index:
机构:
Nagai, Hiroshi
;
Oniki, Shuntaro
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
Oniki, Shuntaro
;
Yoshimoto, Takayuki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Intractable Dis Res Ctr, Tokyo, JapanKobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
Yoshimoto, Takayuki
;
Nishigori, Chikako
论文数: 0引用数: 0
h-index: 0
机构:
Kobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, Japan
机构:
Technion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Flieman Med Ctr, Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Gilhar, Amos
;
Keren, Aviad
论文数: 0引用数: 0
h-index: 0
机构:
Technion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Flieman Med Ctr, Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Keren, Aviad
;
Shemer, Avner
论文数: 0引用数: 0
h-index: 0
机构:
Technion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Flieman Med Ctr, Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Shemer, Avner
;
d'Ovidio, Roberto
论文数: 0引用数: 0
h-index: 0
机构:
Assoc Italiana Dermatol Ambulatoriali, Bari, ItalyTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
d'Ovidio, Roberto
;
Ullmann, Yehuda
论文数: 0引用数: 0
h-index: 0
机构:
Technion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Flieman Med Ctr, Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
Ullmann, Yehuda
;
Paus, Ralf
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ Lubeck, Dept Dermatol, D-23538 Lubeck, Germany
Univ Manchester, Inst Inflammat & Repair, Manchester, Lancs, EnglandTechnion Israel Inst Technol, Fac Med, Skin Res Lab, Haifa, Israel
机构:
Univ Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, EnglandUniv Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, England
Hodgkinson, AD
;
Millward, BA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, EnglandUniv Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, England
Millward, BA
;
Demaine, AG
论文数: 0引用数: 0
h-index: 0
机构:
Univ Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, EnglandUniv Plymouth, Mol Med Res Grp, Plymouth Postgrad Med Sch, Plymouth PL6 8BX, Devon, England