Deletion of the activating NKG2C receptor and a functional polymorphism in its ligand HLA-E in psoriasis susceptibility

被引:33
作者
Zeng, Xue [1 ,2 ]
Chen, Haoyan [1 ,3 ]
Gupta, Rashmi [1 ]
Paz-Altschul, Oscar [1 ]
Bowcock, Anne M. [4 ]
Liao, Wilson [1 ]
机构
[1] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
[2] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Dermatol, Beijing, Peoples R China
[3] Shanghai Jiao Tong Univ, Dept Gastroenterol, Ren Ji Hosp, Sch Med,Shanghai Inst Digest Dis, Shanghai 200030, Peoples R China
[4] Univ London Imperial Coll Sci Technol & Med, Canc Genom & Natl Heart & Lung Inst, London, England
关键词
HLA-E; KLRC2; natural killer; NKG2C; psoriasis; GENOME-WIDE ASSOCIATION; NATURAL-KILLER-CELLS; AUTOIMMUNE-DISEASE; T-CELLS; GENE; MODEL; RISK; SKIN;
D O I
10.1111/exd.12233
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Psoriasis is an inflammatory, immune-mediated disease of the skin. Several studies have suggested that natural killer (NK) cells and their receptors may be important for its pathogenesis. Here, we examined whether deletion of the activating natural killer receptor gene NKG2C, which has a frequency of 20% in the European population, was associated with psoriasis susceptibility. The NKG2C deletion and a functional polymorphism in its ligand HLA-E were genotyped in a Caucasian cohort of 611 psoriasis cases and 493 controls. We found that the NKG2C deletion was significantly increased in cases compared with controls [0.258 vs 0.200, P=0.0012, OR=1.43 (1.15-1.79)]. The low-expressing HLA-E*01:01 allele was associated with psoriasis (P=0.0018), although this association was dependent on HLA-C. Our findings support a potential immunoregulatory role for NK cells in psoriasis and suggest the importance of future studies to investigate the contribution of NK cells and their regulatory receptors to the pathogenesis of psoriasis.
引用
收藏
页码:679 / 681
页数:3
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