Association of Interleukin-13 SNP rs20541 (Arg > Gln) to allergic rhinitis in an Asian population of ethnic Chinese in Singapore

被引：8
作者：
Andiappan, Anand Kumar [1 ]
Rotzschke, Olaf [1 ]
Wang, De Yun [2 ]
Chew, Fook Tim [3 ]
机构：
[1] ASTAR, Singapore Immunol Network SIgN, Singapore, Singapore
[2] Natl Univ Singapore, Dept Otolaryngol, Singapore 117548, Singapore
[3] Natl Univ Singapore, Dept Biol Sci, Singapore 117548, Singapore
来源：
GENE | 2013年 / 529卷 / 02期
关键词：
IL-13; rs20541; AR; Singapore Chinese; Genetics; ASTHMA; POLYMORPHISMS; METAANALYSIS; IL-13; IL13; GENES; RISK;
D O I：
10.1016/j.gene.2013.08.014
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In this study, we report our findings as we evaluated the association of IL-13 SNP rs20541 to AR as reported in the meta-analysis (Ying, X-J et al., April, Gene 2013) in an Asian population of 1322 ethnic Chinese recruited in Singapore well defined and characterized for allergic rhinitis. The SNP was significantly associated with AR at an odds ratio of 157 for the homozygous genotype comparisons indicating a strong risk for AR. This highlights the importance of this mutation in Asian populations for risk towards allergic phenotypes and also warrants further functional work to characterize the mechanism behind this genetic predisposition. (C) 2013 Published by Elsevier B.V.
引用
收藏
页码：357 / 358
页数：2
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