MicroRNAs in acute myocardial infarction: Evident value as novel biomarkers?

被引：35

作者：

Chen, Zhongxiu ^{[1
]}

Li, Chen ^{[1
]}

Lin, Ke ^{[2
]}

Zhang, Qing ^{[1
]}

Chen, Yucheng ^{[1
]}

Rao, Li ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Cardiol, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Dept Cardiovasc Surg, Chengdu, Sichuan, Peoples R China

来源：

ANATOLIAN JOURNAL OF CARDIOLOGY | 2018年 / 19卷 / 02期

关键词：

acute myocardial infarction; microRNAs; biomarkers; atherosclerotic plaques; platelet activation; CORONARY-ARTERY-DISEASE; CIRCULATING MICRORNAS; PLATELET REACTIVITY; PERIPHERAL-BLOOD; PLASMA; INTERVENTION; SIGNATURES; DIAGNOSIS; EVENTS; MARKER;

D O I：

10.14744/AnatolJCardiol.2017.8124

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Traditional circulating biomarkers play a fundamental role in the diagnosis and prognosis of acute myocardial infarction (AMI). However, they have several limitations. microRNAs (miRs), a class of RNA molecules that do not encode proteins, function directly at the RNA level by inhibiting the translation of messenger RNAs. Due to their significant roles in disease development, they can be used as biomarkers. Accumulating evidence has revealed an attractive role of miRs as biomarkers of AMI and its associated symptoms, including vulnerable atherosclerotic plaques, and their role in disease diagnosis, platelet activation monitoring, and prognostic outcome prediction. This manuscript will highlight the recent updates regarding the involvement of miRs as biomarkers in AMI and emphasize their value in vulnerable atherosclerotic plaque prediction and monitoring of platelet activation.

引用

页码：140 / 147

页数：8

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