Management of infection in systemic lupus erythematosus

被引：33
作者：
Sciascia, Savino [1 ]
Cuadrado, Maria Jose [1 ]
Karim, Mohammed Yousuf [1 ]
机构：
[1] St Thomas Hosp, Rayne Inst, Lupus Res Unit, London SE1 7EH, England
来源：
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2013年 / 27卷 / 03期
关键词：
Bacterial viral fungal flare; Vaccination; Vaccine antibiotic prophylaxis; Immunoglobulin; MYCOBACTERIUM-TUBERCULOSIS INFECTION; HUMAN-PAPILLOMAVIRUS VACCINE; RISK-FACTORS; INFLUENZA VACCINATION; CYTOMEGALOVIRUS-INFECTION; ISONIAZID PROPHYLAXIS; RHEUMATOID-ARTHRITIS; VARICELLA VACCINE; SAFETY; MORTALITY;
D O I：
10.1016/j.berh.2013.07.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal autoantibody production and clearance. This immunological background has been suggested to play a role in the susceptibility of SLE patients to infection. Moreover, drugs (most of them immunosuppressive or immunomodulating agents) used in the treatment of moderate and severe lupus give rise to a tendency for infections, including opportunistic ones. Infections may mimic the exacerbations of SLE, leading to confusion over the diagnosis and appropriate treatment. Despite increased awareness of this problem, infections remain a major source of morbidity and mortality in SLE. There are various strategies which can be applied to try and reduce the risk of infection in SLE patients. Options include vaccinations, antibiotic/antiviral prophylaxis and intravenous immunoglobulins. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：377 / 389
页数：13
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