Signal transduction and actin filament organization

被引：272
作者：
Zigmond, SH
机构：
[1] Biology Department, University of Pennsylvania, Philadelphia
来源：
CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 01期
关键词：
D O I：
10.1016/S0955-0674(96)80050-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Small GTP-binding proteins of the Rho family appear to integrate extracellular signals from diverse receptor types and initiate rearrangements of F-actin. Active members of the Rho family, Rho and Rac, are now joined by Cdc42 which induces filopodia. Downstream of the Rho family proteins, actin polymerization may be induced by an increase in the availability of actin filament barbed ends. Actin organization may be affected by exposure of actin-binding sites on proteins such as vinculin and ezrin.
引用
收藏
页码：66 / 73
页数：8
相关论文
共 90 条
[31]   PHOSPHOINOSITIDES AND CALCIUM AS REGULATORS OF CELLULAR ACTIN ASSEMBLY AND DISASSEMBLY [J].
JANMEY, PA .
ANNUAL REVIEW OF PHYSIOLOGY, 1994, 56 :169-191
[32]   F-ACTIN BINDING-SITE MASKED BY THE INTRAMOLECULAR ASSOCIATION OF VINCULIN HEAD AND TAIL DOMAINS [J].
JOHNSON, RP ;
CRAIG, SW .
NATURE, 1995, 373 (6511) :261-264
[33]   SALMONELLA-TYPHIMURIUM INDUCES MEMBRANE RUFFLING BY A GROWTH FACTOR-RECEPTOR-INDEPENDENT MECHANISM [J].
JONES, BD ;
PATERSON, HF ;
HALL, A ;
FALKOW, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10390-10394
[34]   IDENTIFICATION OF 2 17-KDA RAT PAROTID-GLAND PHOSPHOPROTEINS, SUBJECTS FOR DEPHOSPHORYLATION UPON BETA-ADRENERGIC STIMULATION, AS DESTRIN-LIKE AND COFILIN-LIKE PROTEINS [J].
KANAMORI, T ;
HAYAKAWA, T ;
SUZUKI, M ;
TITANI, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (14) :8061-8067
[35]   REGULATION OF HUMAN-LEUKOCYTE P21-ACTIVATED KINASES THROUGH G-PROTEIN-COUPLED RECEPTORS [J].
KNAUS, UG ;
MORRIS, S ;
DONG, HJ ;
CHERNOFF, J ;
BOKOCH, GM .
SCIENCE, 1995, 269 (5221) :221-223
[36]   PHOSPHOINOSITIDE 3-KINASE INHIBITION SPARES ACTIN ASSEMBLY IN ACTIVATING PLATELETS BUT REVERSES PLATELET-AGGREGATION [J].
KOVACSOVICS, TJ ;
BACHELOT, C ;
TOKER, A ;
VLAHOS, CJ ;
DUCKWORTH, B ;
CANTLEY, LC ;
HARTWIG, JH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (19) :11358-11366
[37]  
KOZMA R, 1995, MOL CELL BIOL, V15, P1942
[38]  
LAMARCHE N, 1994, TRENDS GENET, V10, P346
[39]   REGULATION OF CORTICAL ACTIN CYTOSKELETON ASSEMBLY DURING POLARIZED CELL-GROWTH IN BUDDING YEAST [J].
LI, R ;
ZHENG, Y ;
DRUBIN, DG .
JOURNAL OF CELL BIOLOGY, 1995, 128 (04) :599-615
[40]   INTEGRIN-MEDIATED TYROSINE PHOSPHORYLATION AND CYTOKINE MESSAGE INDUCTION IN MONOCYTIC CELLS - A POSSIBLE SIGNALING ROLE FOR THE SYK TYROSINE KINASE [J].
LIN, TH ;
ROSALES, C ;
MONDAL, K ;
BOLEN, JB ;
HASKILL, S ;
JULIANO, RL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (27) :16189-16197
123456789