Reaction-diffusion systems for the macroscopic bidomain model of the cardiac electric field

被引:87
作者
Veneroni, Marco [1 ]
机构
[1] Eindhoven Univ Technol, Dept Math & Comp Sci, NL-5600 MB Eindhoven, Netherlands
关键词
Reaction-diffusion equations; Bidomain model; Degenerate evolution equations; 3-D MODELS; TISSUE; EXCITATION; ANISOTROPY; EVOLUTION; HOMOGENIZATION; REPOLARIZATION; SIMULATIONS; PROPAGATION; ACTIVATION;
D O I
10.1016/j.nonrwa.2007.11.008
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
The paper deals with a mathematical model for the electric activity of the heart at the macroscopic level. The membrane model used to describe the ionic currents is a generalization of the phase-I Luo-Rudy, a model widely used in 2-D and 3-D simulations of the propagation of the action potential. From the mathematical viewpoint the model is made up of a degenerate parabolic reaction diffusion system coupled with an ODE system. We derive existence, uniqueness and some regularity results. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:849 / 868
页数:20
相关论文
共 57 条
[41]   Models of cardiac ventricular action potentials: iterative interaction between experiment and simulation [J].
Noble, D ;
Rudy, Y .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2001, 359 (1783) :1127-1142
[42]   Multiscale modeling for the bioelectric activity of the heart [J].
Pennacchio, M ;
Savaré, G ;
Colli-Franzone, P .
SIAM JOURNAL ON MATHEMATICAL ANALYSIS, 2005, 37 (04) :1333-1370
[43]   Simulation study of cellular electric properties in heart failure [J].
Priebe, L ;
Beuckelmann, DJ .
CIRCULATION RESEARCH, 1998, 82 (11) :1206-1223
[44]   Filament instability and rotational tissue anisotropy: A numerical study using detailed cardiac models [J].
Rappel, WJ .
CHAOS, 2001, 11 (01) :71-80
[45]   A COLLOCATION-GALERKIN FINITE-ELEMENT MODEL OF CARDIAC ACTION-POTENTIAL PROPAGATION [J].
ROGERS, JM ;
MCCULLOCH, AD .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1994, 41 (08) :743-757
[46]   ACTION-POTENTIAL PROPAGATION IN A THICK STRAND OF CARDIAC-MUSCLE [J].
ROTH, BJ .
CIRCULATION RESEARCH, 1991, 68 (01) :162-173
[47]   HOW THE ANISOTROPY OF THE INTRACELLULAR AND EXTRACELLULAR CONDUCTIVITIES INFLUENCES STIMULATION OF CARDIAC-MUSCLE [J].
ROTH, BJ .
JOURNAL OF MATHEMATICAL BIOLOGY, 1992, 30 (06) :633-646
[48]   The induction of reentry in cardiac tissue. The missing link: How electric fields alter transmembrane potential [J].
Roth, BJ ;
Krassowska, W .
CHAOS, 1998, 8 (01) :204-220
[49]   Frequency locking of meandering spiral waves in cardiac tissue [J].
Roth, BJ .
PHYSICAL REVIEW E, 1998, 57 (04) :R3735-R3738
[50]  
Showalter R., 1997, MATH SURVEYS MONOGRA